Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation
Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation
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DOI：
10.1016/j.bbrc.2007.05.148
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发表时间：
2007-08-03
影响因子：
3.1
通讯作者：
Bessho, Kazuhisa
中科院分区：
文献类型：
--
作者：
Murashima-Suginami, Akiko;Takahashi, Katsu;Bessho, Kazuhisa
术语“多生牙”描述了在乳牙或恒牙列中产生超过正常数量的牙齿。其病因不明。子宫致敏相关基因-1（Uterine sensitization associated gene-1，USAG-1）是一种BMP拮抗剂，通过结合和中和BMP活性在BMP信号传导的局部调节中起重要作用，并且也作为Wnt信号传导的调节剂。我们在这里报告USAG-1缺陷小鼠有多生牙。上颌多生门齿似乎是由于上门齿残牙的连续发育而形成的。我们证实USAG-1的表达是本地化的上皮和间充质的残上颌切牙牙齿器官的形成。USAG-1的废除挽救了牙源性间充质细胞的凋亡消除。基于这些结果，我们得出结论，USAG-1控制牙齿的数量在上颌切牙区通过调节细胞凋亡。爱思唯尔公司出版
The term "supernumerary teeth" describes production of more than the normal number of teeth in the primary or permanent dentitions. Their aetiology is not understood. Uterine sensitization associated gene-1 (USAG-1) is a BMP antagonist that plays important roles in the local regulation of BMP signaling by binding and neutralizing BMP activities, and also serves as a modulator of Wnt signaling. We report here that USAG-1 deficient mice have supernumerary teeth. The supernumerary maxillary incisor appears to form as a result of the successive development of the rudimentary upper incisor tooth. We confirmed that the USAG-1 expression is localized to the epithelium and mesenchyme of the rudimentary maxillary incisor tooth organ formation. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. Based upon these results, we conclude that USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis. Published by Elsevier Inc.