Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats
Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats
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DOI：
10.1007/978-1-4614-6093-0_6
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
Seo, Ji-Na
中科院分区：
文献类型：
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作者：
Choi, Mi-Ja;Seo, Ji-Na
本研究旨在探讨膳食中补充牛磺酸对大鼠骨密度(BMD)和骨矿含量(BMC)的影响。雄性SD大鼠20只，体重200±10g，随机分为对照组和牛磺酸组(2%牛磺酸组)。所有大鼠均以实验饲料、去离子水和锂盐喂养6周。测定血清碱性磷酸酶(ALP)活性、骨钙素、甲状旁腺素(PTH)和尿脱氧吡啶交联值作为骨形成和骨吸收的指标。采用美国威斯康星州通用电气公司生产的PIXIMUS骨密度仪测量脊柱和股骨的骨密度和骨密度。饲料对碱性磷酸酶、骨钙素和甲状旁腺素的影响不显著。碱性磷酸酶、骨钙素和甲状旁腺素浓度无显著差异。牛磺酸组大鼠尿钙排泄量低于对照组。牛磺酸组大鼠股骨BMC/体重显著高于对照组。本研究结果提示牛磺酸在雄性大鼠骨代谢中可能起作用。
The purpose of this study was to investigate the effect of dietary taurine supplementation on bone mineral density (BMD) and bone mineral content (BMC) in rats. Twenty Sprague-Dawley male rats (body weight 200 +/- 10 g) were divided into two groups, control and taurine group (2% taurine-supplemented diet). All rats were fed on experimental diet and deionized water and libitum for 6 weeks. Serum alkaline phosphatase (ALP) activity, osteocalcin, PTH, and urinary deoxypyridinoline cross-links value were measured as markers of bone formation and resorption. BMD and BMC were measured using PIXImus (GE Lunar Co., Wisconsin) in spine and femur. The effect of diet on ALP, osteocalcine, and PTH was not significant. There were no significant differences in ALP, osteocalcine, and PTH concentration. Urinary calcium excretion was lower in taurine group than in control group. Femur BMC/weight of taurine group was significantly higher than control group. The results of this study showed the possible role of taurine in bone metabolism in male rats.