Effects of Phytic Acid and Exercise on Some Serum Analytes in Rats Orally Exposed to Diets Supplemented with Cadmium
Effects of Phytic Acid and Exercise on Some Serum Analytes in Rats Orally Exposed to Diets Supplemented with Cadmium
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DOI：
10.1007/s12011-012-9572-9
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发表时间：
2013-03-01
影响因子：
3.9
通讯作者：
Omoruyi, Felix O.
中科院分区：
文献类型：
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作者：
Daley, Tasha;Omoregie, Samson N.;Omoruyi, Felix O.
镉是一种日益受到世界关注的环境污染物。据报告，在牙买加一些教区种植粮食作物的土壤中，该物质含量很高。令人惊讶的是，牙买加人口中没有报告镉的不良影响。然而，在牙买加种植的一些粮食作物中，植酸含量也很高。在这项研究中，我们评估了植酸（1%）和运动对镉（5 mg镉/kg体重）在大鼠体内代谢的影响。五组大鼠饲养如下：大鼠喂养对照饮食，对照饮食补充镉和进行运动，对照饮食补充植酸加镉和进行运动，对照饮食补充镉加植酸，对照饮食补充镉，和对照饮食补充镉。动物喂养4周，然后处死。采集血液样本用于某些生化测定。仅补充镉的组体重减轻百分比（28.42%）最大.与其他试验组相比，喂食补充镉的对照饮食的组仅显示肝酶和电解质增加，但碳酸氢盐显著减少。同样，与其他试验组相比，仅补充镉的组的血尿素氮和尿酸增加。与对照组相比，试验组的总胆固醇呈下降趋势。这些观察结果表明，食用高植酸的饮食和相对较高的体力活动可能对镉的不良影响有保护作用。
Cadmium is an environmental pollutant of increasing worldwide concern. It has been reported to be high in the soil where food crops are grown in some parishes of Jamaica. Surprisingly, no adverse effect of cadmium has been reported among the Jamaican population. However, phytic acid has also been shown to be high in some food crops grown in Jamaica. In this study, we evaluated the effects of phytic acid (1 %) and exercise on the metabolism of cadmium (5 mg cadmium/kg body weight) in rats. Five groups of rats were fed as follows: rats fed control diet, control diet supplemented with cadmium and subjected to exercise, control diet supplemented with phytic acid plus cadmium and subjected to exercise, control diet supplemented with cadmium plus phytic acid, and control diet supplemented with cadmium only. The animals were fed for 4 weeks and then sacrificed. Blood samples were collected for some biochemical assays. Percentage weight loss (28.42 %) was greatest in the group that had cadmium supplement only. The group fed control diet supplemented with cadmium only displayed increased liver enzymes and electrolytes except for the significant decrease in bicarbonate compared to other test groups. Similarly, blood urea nitrogen and uric acid were increased in the group fed cadmium supplement only compared to other test groups. Total cholesterol trended downwards in the test groups compared to control. These observations suggest that consumption of diet high in phytic acid with relatively high physical activity may be protective against the adverse effects of cadmium.