Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review).
Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review).
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DOI：
10.3892/mmr.2018.9577
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发表时间：
2018-10
影响因子：
3.4
通讯作者：
Xiang-hua Yu;Xiao-hua Ren;Xin-hua Liang;Ya-Ling Tang
中科院分区：
文献类型：
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作者：
Xiang-hua Yu;Xiao-hua Ren;Xin-hua Liang;Ya-Ling Tang
脂肪酸（fatty acid，FA）代谢包括FA的摄取、从头合成和氧化，对癌细胞的存活、增殖、分化和转移至关重要。一些证据已经证实了在癌症发展过程中发生的FA的代谢重编程。本综述旨在评估FA在肿瘤发生和肿瘤进展中如何逐渐建立癌症标志，并考虑FA代谢在这些过程中的作用和确切机制。此外，还讨论了肿瘤微环境中的这种相互作用。基于FA代谢在肿瘤发展中的作用，靶向FA代谢可以有效靶向癌症，影响癌症进展和生存的许多重要特征。
Fatty acid (FA) metabolism, including the uptake, de novo synthesis and oxidation of FAs, is critical for the survival, proliferation, differentiation and metastasis of cancer cells. Several bodies of evidence have confirmed the metabolic reprogramming of FAs that occurs during cancer development. The present review aimed to evaluate FAs in terms of how the hallmarks of cancer are gradually established in tumourigenesis and tumour progression, and consider the auxo‑action and exact mechanisms of FA metabolism in these processes. In addition, this interaction in the tumour microenvironment was also discussed. Based on the role of FA metabolism in tumour development, targeting FA metabolism may effectively target cancer, affecting a number of important characteristics of cancer progression and survival.