Two types of chromosome 1p losses with opposite significance in gliomas
Two types of chromosome 1p losses with opposite significance in gliomas
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DOI：
10.1002/ana.20607
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发表时间：
2005-09-01
影响因子：
11.2
通讯作者：
Delattre, JY
中科院分区：
文献类型：
--
作者：
Idbaih, A;Marie, Y;Delattre, JY
1号染色体短臂(1p)缺失被认为是神经胶质瘤的一个有利的预后因素。108个胶质瘤的高密度阵列比较基因组杂交分析显示有两种不同类型的1p缺失。1p的完全缺失与19q缺失和少突胶质细胞表型密切相关，部分1p缺失主要见于星形细胞肿瘤，与19q缺失无关。虽然第一种类型预示着更长的总体和无进展的生存期(P<；0.0001)，而第二种类型具有不利的预后价值。因此，需要对1P臂进行完整的评估，以了解胶质瘤中1P缺失的真正临床意义。
Deletion of the short arm of chromosome 1 (1p) is considered a favorable prognostic factor in glial tumors. High-density array-comparative genomic hybridization analysis of 108 gliomas shows two distinct types of 1p deletions. Complete hemizygous losses of 1p, which are tightly associated with 19q loss and oligodendroglial phenotype, and partial 1p deletions mainly observed in astrocytic tumors and not associated with 19q loss. Whereas the first type predicts longer overall and progression-free survival (p < 0.0001), the second type has a pejorative prognostic value. Complete 1p-arm evaluation therefore is required to appreciate the real clinical significance of 1p loss in gliomas.