Effect of insulin on growth and biochemical composition of the rat fetus.
Effect of insulin on growth and biochemical composition of the rat fetus.
复制标题
胰岛素对大鼠胎儿生长和生化成分的影响。
DOI：
10.1210/endo-81-6-1419
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发表时间：
1967
期刊：
影响因子：
4.8
通讯作者：
L. Picon
中科院分区：
文献类型：
--
作者：
L. Picon
大鼠胚胎每日注射胰岛素3天，第三次注射后24小时处死。注射开始于阴蒂后17、18或19天，因此胎儿在阴蒂后20、21或22天被取出。对活产的胎儿进行鲜重、干重、氮和脂总量的测定。在出生后20天处死的胎儿中，注射胰岛素对这些值没有显著影响。相反，在出生前21天，尤其是出生后22天，胰岛素处理组动物的鲜重、干重、脂肪和氮的总量以及脂/氮比均高于对照组，差异有统计学意义。胰岛素的效果与糖尿病母亲所生婴儿的临床异常进行了比较。通过胰腺切除或四氧嘧啶诱导的糖尿病雌性大鼠后代的实验数据显示，糖尿病雌性大鼠的胰腺切除或四氧嘧啶可导致糖尿病。
Rat fetuses were given daily injections of insulin for 3 days and were sacrificed 24 hr after the third injection. Injections started at 17, 18 or 19 days post coitum (p.c.); hence the fetuses were removed at 20, 21 or 22 days p.c. In the fetuses born alive, fresh weight, dry weight and the total amount of nitrogen and lipids were determined. In fetuses sacrificed at 20 days p.c, insulin injections had no significant effect on these values. On the contrary, in fetuses taken just before delivery at 21 days p.c, and particularly in post-mature fetuses taken at 22 days p.c, fresh weight, dry weight, the total amount of lipids and nitrogen and the lipids/nitrogen ratio were higher in the insulintreated animals than in the controls; the differences between the 2 groups were statistically significant. The effect of insulin is compared to the clinical abnormalities observed in infants born to diabetic mothers. Experimental data, concerning the offspring of female rats made diabetic by pancreatectomy or alloxan i...