A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
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DOI：
10.1016/j.neuroimage.2005.06.058
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发表时间：
2005-11-15
期刊：
影响因子：
5.7
通讯作者：
Van Essen, DC
中科院分区：
文献类型：
--
作者：
Van Essen, DC
这份报告描述了一个新的人类大脑皮层电子图谱，为各种各样的大脑映射分析提供了基础。基于群体平均、地标和表面（帕尔斯）的图谱方法涉及皮质形状的基于表面和基于体积的表示，每个表示都可作为群体平均值和个体受试者数据。这里介绍的特定PALS-B12图谱来自12名正常年轻人的结构MRI体积。为每个半球生成准确的皮质表面重建，并使用SureFit和Caret软件将表面充气、压平并映射到标准球形配置。通过对来自24个贡献半球中的每一个半球的选定标志轮廓取平均值来生成目标寰椎球。每个单独的半球变形到这个目标，使用地标约束的表面配准。所得到的PALS-B12图谱的效用被证明使用各种分析。(i)使用基于表面的配准（SBR）和传统的基于体积的配准（VBR）生成脑沟身份的概率图。SBR方法取得了显着更好的一致性沟对齐比VBR。(H)介绍了一种用于体积平均组数据的“多基准映射”的方法（例如，fMRI数据，概率结构图）到图谱中的每个单独的半球上，然后在各个图上进行空间平均。这就产生了一个群体平均表面表示，避免了选择任何单一半球作为目标的固有偏见。(iii)基于表面和基于体积的形态测量应用于地图的沟深度和沟的身份表现出突出的左右不对称的上级颞沟和侧裂。此外，颞叶的形状变异性在左半球明显大于右半球。PALS-B12地图集已在其他地面地图集上登记，以便利各地图集之间的数据交换和比较。PALS-B12图谱中的所有数据集都可以通过SumsDB数据库进行在线和离线可视化和分析。(c)2005年爱思唯尔公司All rights reserved.
This report describes a new electronic atlas of human cerebral cortex that provides a substrate for a wide variety of brain-mapping analyses. The Population-Average, Landmark- and Surface-based (PALS) atlas approach involves surface-based and volume-based representations of cortical shape, each available as population averages and as individual subject data. The specific PALS-B12 atlas introduced here is derived from structural MRI volumes of 12 normal young adults. Accurate cortical surface reconstructions were generated for each hemisphere, and the surfaces were inflated, flattened, and mapped to standard spherical configurations using SureFit and Caret software. A target atlas sphere was generated by averaging selected landmark contours from each of the 24 contributing hemispheres. Each individual hemisphere was deformed to this target using landmark-constrained surface registration. The utility of the resultant PALS-B12 atlas was demonstrated using a variety of analyses. (i) Probabilistic maps of sulcal identity were generated using both surface-based registration (SBR) and conventional volume-based registration (VBR). The SBR approach achieved markedly better consistency of sulcal alignment than did VBR. (H) A method is introduced for 'multi-fiducial mapping' of volume-averaged group data (e.g., fMRI data, probabilistic architectonic maps) onto each individual hemisphere in the atlas, followed by spatial averaging across the individual maps. This yielded a population-average surface representation that circumvents the biases inherent in choosing any single hemisphere as a target. (iii) Surface-based and volume-based morphometry applied to maps of sulcal depth and sulcal identity demonstrated prominent left-right asymmetries in and near the superior temporal sulcus and Sylvian fissure. :Moreover, shape variability in the temporal lobe is significantly greater in the left than the right hemisphere. The PALS-B12 atlas has been registered to other surface-based atlases to facilitate interchange of data and comparison across atlases. All data sets in the PALS-B12 atlas are accessible via the SumsDB database for online and offline visualization and analysis. (c) 2005 Elsevier Inc. All rights reserved.