DEPOLARIZING RESPONSES TO CAPSAICIN IN A SUBPOPULATION OF RAT DORSAL-ROOT GANGLION-CELLS
DEPOLARIZING RESPONSES TO CAPSAICIN IN A SUBPOPULATION OF RAT DORSAL-ROOT GANGLION-CELLS
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DOI：
10.1016/0304-3940(85)90442-2
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
RANG, HP
中科院分区：
文献类型：
--
作者：
HEYMAN, I;RANG, HP
用微电极记录大鼠背根神经节（DRG）细胞胞体的电生理特性，研究其与辣椒素敏感性的关系。在测试的80个细胞中，有17个细胞对辣椒素反应迅速去极化。这些细胞具有低轴突传导速度（< 1.4 m/s）和长持续时间的动作电位，这是C细胞的特征。一些C细胞对辣椒素没有反应，而具有高传导速度和短暂动作电位的A细胞则没有反应。辣椒素对C细胞电流-电压曲线的影响表明，它产生了电导增加以及延迟整流的变化。
Microelectrode recordings from the somata of rat dorsal root ganglion (DRG) cells were used to correlate their electrophysiological characteristics with sensitivity to locally applied capsaicin. Of the 80 cells tested, 17 responded to capsaicin by a rapid depolarization. These cells had low axonal conduction velocities (< 1.4 m/s) and long duration action potentials, characteristic of C-cells. Some C-cells did not respond to capsaicin, and no A-cells, which had high conduction velocities and brief action potentials, did so. The effect of capsaicin on the current-voltage curve of C-cells suggested that it produced a conductance increase as well as a change in delayed rectification.