Chitosan‐Silicon Phthalocyanine Conjugate as Effective Photo‐Functional Hydrogel for Tracking and Killing of Bacteria
Chitosan‐Silicon Phthalocyanine Conjugate as Effective Photo‐Functional Hydrogel for Tracking and Killing of Bacteria
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DOI：
10.1002/ejoc.202001363
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发表时间：
2020-10
影响因子：
2.8
通讯作者：
Konstantin Strokov;A. Galstyan
中科院分区：
文献类型：
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作者：
Konstantin Strokov;A. Galstyan
水凝胶对于许多生物医学应用来说是有吸引力的材料，包括药物输送和伤口愈合。通过引入适当的光敏剂（PS），可以赋予材料光触发的抗菌活性。在这项研究中，我们合成了水溶性硅（IV）酞菁衍生物（SiPc），其在大环外围含有四个羧基。获得的 PS 不仅可以作为活性发色团，还可以作为交联胶凝剂，从而能够简单轻松地合成壳聚糖缀合物（SiPcCh）。尽管UV/Vis和荧光光谱方法表明游离PS和结合PS在水介质中均不聚集，但只有SiPcCh对革兰氏阳性B具有显着的抗菌作用。枯草芽孢杆菌革兰氏阴性E.大肠杆菌。
Hydrogels are attractive materials for many biomedical applications, including drug delivery and wound healing. A light‐triggered antibacterial activity can be conferred to the material with the introduction of appropriate photosensitizers (PS). In this study, we have synthesized water‐soluble silicon(IV)phthalocyanine derivative (SiPc) that contains four carboxylic groups on the periphery of the macrocycle. Obtained PS serves not only as an active chromophore but also as a cross‐linking gelator, enabling simple and easy synthesis of chitosan conjugate (SiPcCh). Although UV/Vis and fluorescence spectroscopic methods showed that both free and conjugated PS are non‐aggregated in water media, only SiPcCh possess remarkable antibacterial effect against Gram‐positiveB. subtilisand Gram‐negativeE. coli.