Effects of electrical and chemical stimulation of nucleus raphe magnus on responses to renal nerve stimulation.
Effects of electrical and chemical stimulation of nucleus raphe magnus on responses to renal nerve stimulation.
复制标题
中缝大核的电和化学刺激对肾神经刺激反应的影响。
DOI：
10.1016/0006-8993(91)90045-w
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发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Holt,IL
中科院分区：
文献类型：
--
作者：
Knuepfer,MM;Holt,IL
电刺激中缝大核（NRM）抑制脊髓水平的某些躯体和内脏输入。本研究旨在探讨电刺激和化学刺激中缝大核对刺激肾传入神经（ARN）神经元反应的影响。在氯醛糖麻醉大鼠，电刺激ARN引起脊髓灰质神经元的兴奋性反应为主。在10个神经元中，电刺激中缝大核可抑制8个神经元的自发活动，抑制6个神经元对ARN刺激的诱发反应。将5-10 nmol谷氨酸（0.5-1 μl）注入中缝大核（NRM），可使9个神经元的自发活动受到抑制，6个神经元的自发活动受到易化，8个神经元对ARN输入无反应。刺激ARN引起的反应在12个神经元中被抑制，在4个神经元中被易化，在8个神经元中不受影响。我们的结论是，肾输入可以调制在脊髓水平的激活NRM和邻近组织。此外，由于非选择性电刺激比神经元索马和树突的选择性化学刺激更有效，因此刺激NRM引起的脊髓灰质神经元反应的抑制似乎至少部分是由于通道纤维的激活。
Electrical stimulation of the nucleus raphe magnus (NRM) inhibits some somatic and visceral input at the spinal level. This study was designed to examine the effects of electrical and chemical stimulation of NRM on neuronal responses to afferent renal nerve (ARN) stimulation. In chloralose-anesthetized rats, electrical stimulation of ARN elicited predominantly excitatory responses in spinal gray neurons. In 10 neurons studied, electrical stimulation of the NRM elicited an inhibition of spontaneous activity of 8 neurons and inhibited evoked responses to ARN stimulation in 6 neurons. Microinjection of glutamate (5–10 nmol in 0.5–1 μl) into the NRM elicited an inhibition of spontaneous activity in 9 neurons, a facilitation in 6 neurons and no response in 8 neurons receiving ARN input. Responses evoked by ARN stimulation were inhibited in 12 neurons, facilitated in 4 neurons and not affected in 8 neurons. We conclude that renal input can be modulated at the spinal level by activation of the NRM and adjacent tissue. Furthermore, the inhibition of spinal gray neuronal responses elicited by stimulation of the NRM appears to be due, at least in part, to activation of fibers of passage since non-selective electrical stimulation is more efficacious than selective chemical stimulation of neuronal soma and dendrites.