Amygdala activation during unconscious visual processing of food
Amygdala activation during unconscious visual processing of food
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DOI：
10.1038/s41598-019-43733-2
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发表时间：
2019-05-13
影响因子：
4.6
通讯作者：
Fushiki，Tohru
中科院分区：
文献类型：
--
作者：
Sato，Wataru;Kochiyama，Takanori;Fushiki，Tohru
对食物的享乐或情绪反应对人类生活具有重要的积极和消极影响。行为研究表明，即使在没有对食物有意识的情况下，对食物图像的享乐反应也会迅速引发。尽管之前的一些神经影像学研究调查了有意识处理食物图像期间的神经活动，但无意识食物处理背后的神经机制仍然未知。为了研究这个问题，我们使用功能磁共振成像测量神经活动，同时参与者观看潜意识和超阈值呈现的食物和马赛克图像。联合分析表明，在阈下和阈上条件下，双侧杏仁核对食物图像的反应比对马赛克图像的反应更强烈。交互分析显示，与阈下条件相比，当参与者在阈上条件下观看食物与马赛克图像时，在梭状回后部达到峰值的宽阔双侧后部区域特别活跃。动态因果模型分析支持了这样的模型：从枕丘到杏仁核的皮层下视觉通路在阈下条件下受到食物的调节；相比之下，皮层下和皮层（连接初级视觉皮层、梭状回和杏仁核）视觉通路均受食物调节的模型在超阈值条件下得到了最多的支持。这些结果表明，对食物的无意识享乐反应可能通过皮层下视觉通路激活杏仁核来发挥作用。
Hedonic or emotional responses to food have important positive and negative effects on human life. Behavioral studies have shown that hedonic responses to food images are elicited rapidly, even in the absence of conscious awareness of food. Although a number of previous neuroimaging studies investigated neural activity during conscious processing of food images, the neural mechanisms underlying unconscious food processing remain unknown. To investigate this issue, we measured neural activity using functional magnetic resonance imaging while participants viewed food and mosaic images presented subliminally and supraliminally. Conjunction analyses revealed that the bilateral amygdala was more strongly activated in response to food images than to mosaic images under both subliminal and supraliminal conditions. Interaction analyses revealed that the broad bilateral posterior regions, peaking at the posterior fusiform gyrus, were particularly active when participants viewed food versus mosaic images under the supraliminal compared with the subliminal condition. Dynamic causal modeling analyses supported the model in which the subcortical visual pathway from the pulvinar to the amygdala was modulated by food under the subliminal condition; in contrast, the model in which both subcortical and cortical (connecting the primary visual cortex, fusiform gyrus, and the amygdala) visual pathways were modulated by food received the most support under the supraliminal condition. These results suggest the possibility that unconscious hedonic responses to food may exert an effect through amygdala activation via the subcortical visual pathway.