Combined T1-based perfusion MRI and MR angiography in kidney: First experience in normals and pathology
Combined T1-based perfusion MRI and MR angiography in kidney: First experience in normals and pathology
复制标题
DOI：
10.1016/j.ejrad.2007.11.033
复制
发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
de Mey, Johan
中科院分区：
文献类型：
--
作者：
Duiardin, Martine;Luypaert, Rob;de Mey, Johan
目的：探讨在常规MRA方案中实施定量T1灌注的可行性，并获得正常和病理学的初步经验。材料和方法：对于灌注成像，IR准备的FLASH（一个4 mm切片，位于肾中水平，TR 4.4 ms，TE 2.2 ms，TI 180 ms，FA 50度，矩阵128 x 256，每像素带宽300，400动态，时间分辨率0.3 s，总测量时间2 min），同时以2 ml/s的速度注射10 ml 0.5 mmol/ml的标准Gadolinium-DTPA溶液，然后进行3DCE-MRA和团注追踪（TR 5.4，TE 1.4，FA 40度，矩阵192 x 512，NSA 1，切片厚度1.5 mm），使用第二剂量0.1 mmol Gadolinium-DTPA/kg体重，最大剂量为20 ml。T1加权信号（灌注数据）被转换为组织示踪剂浓度和反卷积与流入校正AIF;血流量，分布体积，平均通过时间和血流heterogeneouswered.Results：MRA质量是不受影响的第一团给予灌注的目的。在正常人中，平均皮质RBF、RVD和MTT为1.2ml/min/ml（S.D.）。0.3 ml/min/ml）、0.4ml/ml（S.D. 0.1 ml/ml）和21 s（S.D. 4 s）。这些径向基函数值低于文献中发现的值，可能是由于残余AIF流入效应。该技术的灵敏度足以证明改变灌注的例子pathology.Conclusion：结合定量T1-灌注和MRA的非侵入性肾血管筛查的潜力，并可能提供一个解剖和生理评价肾状态。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: To investigate the feasibility of implementing quantitative T1-perfusion in the routine MRA-protocol and to obtain a first experience in normals and pathology.Materials and methods: For perfusion imaging, IR-prepared FLASH (one 4 mm slice at mid-renal level, TR 4.4 ms, TE 2.2 ms, TI 180 ms, FA 50 degrees, matrix 128 x 256, bandwidth per pixel 300, 400 dynamics, temporal resolution 0.3 s, total measurement time 2 min) was applied during the injection of 10 ml of standard 0.5 mmol/ml Gadolinium-DTPA solution at 2 ml/s, followed by 3DCE-MRA with bolus tracking (TR 5.4, TE 1.4, FA 40 degrees, matrix 192 x 512, NSA 1, slice thickness 1.5 mm), using a second dose of 0.1 mmol Gadolinium-DTPA per kg body weight with a maximum of 20 ml. The T1-weighted signals (perfusion data) were converted to tissue tracer concentrations and deconvolved with an inflow corrected AIF; blood flow, distribution volume, mean transit time and blood flow heterogeneity were derived.Results: MRA quality was uncompromised by the first bolus administered for perfusion purposes. In the normals, average cortical RBF, RVD and MTT were 1.2 ml/min/ml (S.D. 0.3 ml/min/ml), 0.4 ml/ml (S.D. 0.1 ml/ml) and 21 s (S.D. 4 s). These RBF values are lower than those found in the literature, probably due to residual AIF inflow effects. The sensitivity of the technique was sufficient to demonstrate altered perfusion in the examples of pathology.Conclusion: Combined quantitative T1-perfusion and MRA have a potential for noninvasive renovascular screening and may provide an anatomical and physiological evaluation of renal status. (C) 2007 Elsevier Ireland Ltd. All rights reserved.