Combined electroencephalography and magnetoencephalography of interictal spikes in benign rolandic epilepsy of childhood
Combined electroencephalography and magnetoencephalography of interictal spikes in benign rolandic epilepsy of childhood
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DOI：
10.1016/j.clinph.2007.11.009
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发表时间：
2008-03-01
影响因子：
4.7
通讯作者：
Baumgartner, Christoph
中科院分区：
文献类型：
--
作者：
Pataraia, Ekaterina;Feucht, Martha;Baumgartner, Christoph
目的：方法：采用143通道全头脑磁图（MEG）系统对24例儿童良性罗兰式癫痫（BREC）患者进行了神经电和神经磁联合研究，同时记录了40个密集头皮EEG电极的脑电图（EEG）。在尖峰负峰最大值之前250 ms至之后250 ms的时间窗口内计算等电位和等场图。然后，我们进行了主成分分析（PCA）和时空偶极建模，以估计的数量，位置和时间的活动sources.Results：EEG和MEG尖峰的特点是一个刻板的外观内和跨患者显示一个稳定的偶极场分布在整个时间窗口。结论：位于中央前回的一个源可以充分解释BREC的锋电位复合体，意义：同步EEG和MEG为BREC锋电位的功能组织提供了全面的信息。(C)2007年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: The neurogenesis and functional organization of the interictal spikes in benign rolandic epilepsy of childhood (BREC) still e remains controversial.Methods: We performed a combined neuroelectric and neuromagnetic study in 24 consecutive patients with BREC using a 143-channel whole-head magnetoencephalography (MEG) system simultaneously with electroencephalography (EEG) recorded from 40 closely spaced scalp-EEG electrodes. Isopotential and isofield maps were calculated over the time window from 250 ms before to 250 ms after the maximum of the negative peak of the spike. We then performed principal component analysis (PCA) and spatio-temporal dipole modeling in order to estimate the number, location and temporal activity of sources.Results: EEG and MEG spikes were characterized by a stereotypical appearance both within and across patients showing a stable dipolar field distribution over the entire time window. The spikes were generated by a single tangential dipolar source located in the precentral gyrus with the positive pole directed frontally and the negative pole directed centro-temporally.Conclusions: One source located in the precentral gyrus can adequately explain the spike complex in BREC.Significance: simultaneous EEG and MEG provide comprehensive information on functional organization of spikes in BREC. (C) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.