Diagnostic and prognostic significance of different antinuclear antibodies in more than 1000 consecutive Albanian patients with rheumatic diseases.
Diagnostic and prognostic significance of different antinuclear antibodies in more than 1000 consecutive Albanian patients with rheumatic diseases.
复制标题
超过 1000 名连续阿尔巴尼亚风湿性疾病患者中不同抗核抗体的诊断和预后意义。
DOI：
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发表时间：
1992
影响因子：
3.7
通讯作者：
K. Morcka
中科院分区：
文献类型：
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作者：
G. Sulcebe;K. Morcka
在连续1390例阿尔巴尼亚风湿性疾病（RD）和其他杂项非风湿性疾病（MNRD）患者中，要求进行抗核抗体（ANA）检测，我们计算了ANA阳性结果、ANA滴度超过1：100、抗天然DNA（nDNA）、抗Sm、抗U1 RNP、抗SSA（Ro）、抗SSB（La）和抗未鉴定可提取核抗原（NIENA）抗体的诊断灵敏度、特异性和阳性预测值（PPV）。ANA各型阳性预测值仅对系统性红斑狼疮（SLE）有意义，仅SLE的阳性预测值（26.4%）低于RA的阳性预测值（34.3%）。抗snRNP（Sm/U1 RNP）阳性的SLE患者比抗snRNP阴性的SLE患者更容易出现ARA ≥ 4项SLE诊断标准、ANA滴度≥ 1：100和抗nDNA抗体。抗ENA抗体阳性和抗nDNA抗体阳性的SLE患者肾脏疾病的发生率高于抗ENA抗体阳性和抗nDNA抗体阴性的SLE患者，其肾脏疾病的发生率高于SLE标准的4倍，ANA滴度高于1：100。我们的数据表明，抗snRNP抗体与更严重形式的SLE的关联并不归因于这些抗体本身，而是与抗nDNA抗体的伴随存在密切相关。
In an unselected population of 1390 consecutive Albanian patients with rheumatic diseases (RD) and other miscellaneous non-rheumatic diseases (MNRD), for whom antinuclear antibody (ANA) testing was requested, we calculated the diagnostic sensitivity, specificity and positive predictive value (PPV) of ANA positive results, ANA titres over 1:100, anti-native DNA (nDNA), anti-Sm, anti-U1 RNP, anti-SSA (Ro) anti-SSB (La) and anti-non-identified extractable nuclear antigen (NIENA) antibodies. The PPVs of these ANA types were found to be appreciable only for systemic lupus erythematosus (SLE); only the positive predictive value of ANA for SLE (26.4%) was lower than that for RA (34.3%). The anti-snRNP (Sm/U1RNP) positive SLE patients were more likely to have over 4 of the ARA criteria for SLE, ANA titres over 1:100, and anti-nDNA antibodies, in contrast with the anti-snRNP negative subgroup. On the other hand, the anti-ENA positive and anti-nDNA positive SLE patients generally showed higher frequencies of renal disease, over 4 of the criteria for SLE and ANA titres over 1:100, compared to anti-ENA positive and anti-nDNA negative patients. Our data suggest that the association of anti-snRNP antibodies with a more severe form of SLE is not to be attributed to these antibodies themselves, but rather to their close association with the concomitant presence of anti-nDNA antibodies.