Morphologic and histologic outcomes of tongue reduction surgery in an animal model
Morphologic and histologic outcomes of tongue reduction surgery in an animal model
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DOI：
10.1016/j.otohns.2008.05.018
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发表时间：
2008-08-01
影响因子：
3.4
通讯作者：
Liu, Zi-Jun
中科院分区：
文献类型：
--
作者：
Perkins, Jonathan A.;Shcherbatyy, Volodymyr;Liu, Zi-Jun
目的：设计：前瞻性实验，材料：22只12周龄尤卡坦小型猪，方法：6对同胞猪行舌缩小术（B组）或假手术（A组），手术当天实施安乐死。五对兄弟姐妹进行了舌头缩小术（D组）或假手术（C组），并提高了四周。收集的数据包括舌形态学，组织学和动物对surgery.RESULTS的反应的变化：所有动物耐受手术，并保持他们的体重。与假手术相比，所有动物的舌头大小均匀减小。D组舌缩小长期稳定。所有动物的伤口均正常愈合，神经血管结构保留。结论：中线舌缩小术可使舌各向同性缩小，且不损伤神经血管结构。局部纤维化是愈合的后遗症。(C)2008年美国耳鼻咽喉头颈外科学会基金会。All rights reserved.
OBJECTIVE: To describe the effect of anterior tongue reduction surgery on tongue size, morphology, and histology.DESIGN: Prospective experiment.MATERIALS: Twenty-two 12-week-old Yucatan minipigs.METHODS: Six sibling pairs had tongue reduction (Group B) or sham surgery (Group A), and underwent euthanasia the day of surgery. Five sibling pairs had tongue reduction (Group D) or sham surgery (Group C), and were raised for four weeks. Data collected included changes in tongue morphology, histology, and animal response to surgery.RESULTS: All animals tolerated surgery and maintained their weight. Tongue size was uniformly reduced in all animals as compared to sham surgery. Tongue reduction was stable long term in Group D. All animals had normal wound healing and neurovascular structure preservation. Fibrosis occurred at the repair site.CONCLUSION: Midline tongue reduction resulted in uniform tongue reduction in all dimensions and volume, without damaging neurovascular structures. Localized fibrosis is a sequela of healing. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.