miR-34a expands myeloid-derived suppressor cells via apoptosis inhibition
miR-34a expands myeloid-derived suppressor cells via apoptosis inhibition
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miR-34a 通过抑制细胞凋亡来扩增骨髓源性抑制细胞。
DOI：
10.1016/j.yexcr.2014.04.010
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发表时间：
2014-08-15
影响因子：
3.7
通讯作者：
Zhang, Jinping
中科院分区：
文献类型：
--
作者：
Huang, Anfei;Zhang, Haitao;Zhang, Jinping
骨髓源性抑制细胞（MDSC）是一个异质性群体，在病理条件下表现出显着的扩增。microRNA在许多生物学过程中发挥着重要作用，但microRNA是否在MDSC的扩增中发挥作用仍不十分清楚。本研究中，miR-34 a过表达可以诱导骨髓嵌合体和转基因小鼠模型中MDSCs的扩增。实验结果表明，miR-34 a可抑制MDSCs的凋亡，但不影响MDSCs的增殖。野生型MDSC和miR-34 a过表达MDSC的不同mRNA微阵列谱与miR-34 a的靶预测相结合，表明miR-34 a可能靶向p2 rx 7、Tia 1和plekhf 1等基因以抑制MDSC的凋亡。总之，miR-34 a通过抑制MDSC的凋亡而有助于MDSC的扩增。(C)版权所有© 2014 Elsevier Inc.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population and show significant expansion under pathological conditions. microRNA plays important roles in many biological processes, whether microRNAs have a function in the expansion of MDSCs is still not very clear. In this study, miR-34a overexpression can induce the expansion of MDSCs in bone marrow chimera and transgenic mice model. The experimental results suggest that miR-34a inhibited the apoptosis of MDSCs but did not affect the proliferation of MDSCs. The distinct mRNA microarray profiles of MDSCs of wild type and miR-34a over-expressing MDSCs combined with the target prediction of miR-34a suggest that miR-34a may target genes such as p2rx7, Tia1, and plekhf1 to inhibit the apoptosis of MDSCs. Taken together, miR-34a contributes to the expansion of MDSCs by inhibiting the apoptosis of MDSCs. (C) 2014 Elsevier Inc All rights reserved.