High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma
High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma
复制标题
DOI：
--
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
K. Kanaya;K. Sakai;K. Hongo;M. Fukushima;M. Kawakubo;Jun;Nakayama
中科院分区：
文献类型：
--
作者：
K. Kanaya;K. Sakai;K. Hongo;M. Fukushima;M. Kawakubo;Jun;Nakayama
去整合素和金属蛋白酶10(ADAM10)是ADAM家族锌蛋白水解酶家族的成员之一，参与多种细胞表面分子胞外区的脱落。包括ADAM10在内的几个ADAM家族成员与肿瘤的生长和发展有关，但ADAM10在胶质母细胞瘤中的表达对临床的影响尚不清楚。ADAM10在Notch1信号转导中起重要作用，因此我们用免疫组织化学方法检测了50例IDH1野生型胶质母细胞瘤中ADAM10和Notch1的表达。ADAM10在11例肿瘤标本中高表达，在39例肿瘤标本中低表达。正常脑组织中未见ADAM10的表达。ADAM10与Notch1表达呈正相关(P=0.002)。在我们的研究中，ADAM10的低表达有延长生存期的趋势。综上所述，ADAM10和Notch1在胶质母细胞瘤中的表达呈正相关，ADAM10的表达可能与肿瘤的生长有关，并可作为判断胶质母细胞瘤患者预后的指标。
: A disintegrin and metalloprotease 10 (ADAM10) is a member of the ADAM family of zinc proteases, which are involved in the shedding of extracellular domains of various cell surface molecule. Several ADAM family mem-bers, including ADAM10, have been implicated in cancer growth and progression, however the clinical impact of ADAM10 expression in glioblastoma remains unclear. ADAM10 has an essential role in Notch1 signaling, therefore, we examined the expressions of ADAM10 and Notch1 by immunohistochemistry in 50 patients with IDH1 wild-type glioblastoma. ADAM10 was highly expressed in the tumor specimen of 11 patients but ADAM10 was lowly expressed in 39 patients. No ADAM10 expression was found in normal brain tissue. ADAM10 expression was positively correlated with Notch1 expression (P = 0.002). Low expression of ADAM10 had a tendency to be longer survival in our study. In conclusion, the expression of ADAM10 had a correlation with that of Notch1 in glioblastoma and ADAM10 expression might correlate with tumor growth and be a prognostic factor for patients with glioblastoma.