Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in 13C NMR Spectroscopy.
Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in 13C NMR Spectroscopy.
复制标题
采用高 Q 因子 HTS 谐振器来增强 13C NMR 光谱中的探头灵敏度。
DOI：
10.1088/1742-6596/2323/1/012030
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Brey,WW
中科院分区：
文献类型：
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作者：
Thomas,JN;Johnston,TL;Litvak,IM;Ramaswamy,V;Merritt,ME;Rocca,JR;Edison,AS;Brey,WW
使用薄膜高温超导（HTS）谐振器的核磁共振波谱（NMR）探针在天然产物化学和代谢组学的小样本核磁共振实验中提供了卓越的质量灵敏度。我们报告了基于高温超导谐振器的1.5 mm 13c优化核磁共振探头灵敏度的改进。该探针的样本量为35微升，在14.1 T的磁铁中运行。该探头还具有用于1h传输和探测的高温超导谐振器以及2h锁。探头采用13c谐振器设计，比我们以前的设计提供更高的效率。在14.1 T的背景场中，新谐振器的质量因子为4300，是之前设计的3倍以上。为了有效地实现改进的质量因子，我们演示了增加短传输线存根的效果，以增加带宽和减少13c辐照脉冲的上升/下降时间。初始核磁共振测量验证13c核磁共振灵敏度显着提高，同时保留检测带宽。该探针将用于代谢组学研究。
Nuclear magnetic resonance spectroscopy (NMR) probes using thin-film high temperature superconducting (HTS) resonators provide exceptional mass sensitivity in small-sample NMR experiments for natural products chemistry and metabolomics. We report improvements in sensitivity to our 1.5 mm 13 C-optimized NMR probe based on HTS resonators. The probe has a sample volume of 35 microliters and operates in a 14.1 T magnet. The probe also features HTS resonators for 1 H transmission and detection and the 2 H lock. The probe utilizes a 13 C resonator design that provides greater efficiency than our previous design. The quality factor of the new resonator in the 14.1 T background field was measured to be 4,300, which is over 3x the value of the previous design. To effectively implement the improved quality factor, we demonstrate the effect of adding a shorted transmission line stub to increase the bandwidth and reduce the rise/fall time of 13 C irradiation pulses. Initial NMR measurements verify 13 C NMR sensitivity is significantly improved while preserving detection bandwidth. The probe will be used for applications in metabolomics.