Fronto-temporal-lobe atrophy in early-stage Alzheimer's disease identified using an improved detection methodology
Fronto-temporal-lobe atrophy in early-stage Alzheimer's disease identified using an improved detection methodology
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DOI：
10.1016/j.pscychresns.2006.12.013
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发表时间：
2007-05-15
影响因子：
2.3
通讯作者：
Woodruff, Peter W. R.
中科院分区：
文献类型：
--
作者：
Farrow, Tom F. D.;Thiyagesh, Subha N.;Woodruff, Peter W. R.
阿尔茨海默氏病 (AD) 与广泛的脑萎缩（包括维护记忆的结构）有关。我们应用了改进的结构检测方法来检查早期 AD 中不太为人所知的萎缩进展。我们试图 i) 纵向研究早期 AD 患者和健康志愿者的体积差异； ii) 检验海马体积与临床相关认知功能相关的假设。七名患者和十一名健康受试者接受了两次结构 MRI 扫描和神经心理学评估。扫描被标准化为研究特定的模板，并且“形态学打开”以减少组织错误分类。使用大脑分区，患者萎缩定位于左侧梭状回和海马旁回，而左侧海马体积与认知表现测量相关。全脑搜索方法显示，患者的体积减少，包括双侧额颞区、海马体、杏仁核和右侧小脑。全脑相关分析显示，认知表现与海马体、颞上回和左岛叶的体积相关。两组均未表现出显着的纵向体积变化。利用一种新的方法，我们已经证明，在早期 AD 中，临床相关的认知缺陷与区域特定的灰质体积相关，这些灰质体积在疾病的早期阶段是可以检测到的。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Alzheimer's disease (AD) is associated with widespread brain atrophy including structures subserving memory. We applied an improved structural detection methodology to, examine the less well known progression of atrophy in early-stage AD. We sought to i) longitudinally study volumetric differences in patients with early-stage AD and healthy volunteers; and ii) test the hypothesis that hippocampal volumes would be correlated with clinically relevant cognitive function. Seven patients and eleven healthy subjects underwent two structural MRI scans and neuropsychological assessments. Scans were normalised to a study-specific template and,morphologically opened' to reduce tissue misclassification. Using brain-parcellation, patient atrophy was localised to left fusiform and parahippocampal gyri, whilst left hippocampal volumes were correlated with a cognitive performance measure. A whole-brain search methodology, showed that patients had reduced volumes including fronto-temporal regions bilaterally, in hippocampi and amygdalae and right cerebellum. Whole-brain correlational analyses revealed that cognitive performance was correlated with volumes of both hippocampi, superior temporal gyri and left insula. Neither group exhibited significant longitudinal volumetric changes. Utilising a novel methodology, we have shown that in early-stage AD, clinically relevant cognitive deficits are correlated with regionally specific grey-matter volumes, which are detectable at an early stage of the illness. (c) 2007 Elsevier Ireland Ltd. All rights reserved.