Clinical evaluation of human papillomavirus 16/18 oncoprotein test for cervical cancer screening and HPV positive women triage
Clinical evaluation of human papillomavirus 16/18 oncoprotein test for cervical cancer screening and HPV positive women triage
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DOI：
10.1002/ijc.31368
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发表时间：
2018-08-15
影响因子：
6.4
通讯作者：
Qiao, You-Lin
中科院分区：
文献类型：
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作者：
Yu, Lulu;Jiang, Mingyue;Qiao, You-Lin
HPV-16和-18约占宫颈癌的80%。我们评估了HPV-16/18癌蛋白在相应组织活检标本中预测癌前和癌的性能。从4家医院招募1008名参加宫颈癌筛查项目的妇女和638名经阴道镜检查证实宫颈上皮内瘤变2级或更严重（CIN2+）的妇女（共1646名）。所有女性均进行了OncoE6 （AVC）、液体细胞学（Hologic）和cobas HPV检测（Roche）。对有异常结果的妇女进行阴道镜检查。最终的诊断是基于对组织学的一致评估。正常919例，CIN1 69例，CIN2 53例，CIN1 91例，鳞状细胞癌（SCC） 3474例，腺癌（ADC） 40例，其中OncoE6的患病率分别为1.7%,10.1%,13.2%,44.0%，80.4%和65.0%。cobas阳性检出率高于OncoE6阳性检出率(p
HPV-16 and -18 account for about 80% of cervical cancers. We evaluated the performance of HPV-16/18 oncoprotein to predict precancer and cancer in corresponding tissue biopsy specimens. 1,008 women attending cervical cancer screening program and 638 women referred to colposcopy with biopsy-confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) from 4 hospitals were recruited (1,646 in total). All women were tested OncoE6 (AVC), Liquid-Based Cytology (Hologic) and cobas HPV test (Roche). Colposcopy was performed on women with any abnormal results. The final diagnoses were based on a consensus panel review of the histology. There were 919 normal, 69 CIN1, 53 CIN2, 91 CIN3,474 squamous cell carcinoma(SCC) and 40 adenocarcinoma (ADC) cases, the prevalence of OncoE6 was 1.7%, 10.1%, 13.2%, 44.0%, 80.4% and 65.0%, respectively. The percent positive for cobas was higher than that of OncoE6 in detection of HPV16/18 in entire population (p