Cannabis use and mental health in young people: cohort study
Cannabis use and mental health in young people: cohort study
复制标题
DOI：
10.1136/bmj.325.7374.1195
复制
发表时间：
2002-11-23
影响因子：
105.7
通讯作者：
Hall, W
中科院分区：
文献类型：
--
作者：
Patton, GC;Coffey, C;Hall, W
目的确定青少年时期使用大麻是否会导致青少年时期抑郁和焦虑的发病率较高。设计七波队列研究，为期六年。在澳大利亚维多利亚州设置44所学校。参与者：全州范围内的1601名14-15岁学生的中学样本，随访七年。主要结果测量抑郁和焦虑的访谈测量结果约60%的参与者在20岁之前使用过大麻; 7%的人在那时每天使用大麻。年轻女性每日使用与报告抑郁和焦虑状态的几率增加5倍以上相关，调整了其他物质的并发使用后（比值比5.6，95%置信区间2.6至12）。青少年每周或更频繁地使用大麻，在调整潜在的基线混杂因素后，预测后期抑郁和焦虑的风险增加约两倍（1.9，1.1至3.3）。相比之下，抑郁和焦虑的青少年预测以后每周或每天cannabuse.Conclusions经常使用大麻的少女预测以后的抑郁和焦虑，与日常用户携带的风险最高。鉴于最近大麻使用量不断增加，似乎有必要采取措施减少频繁和大量的娱乐性使用。
Objective To determine whether cannabis use in adolescence predisposes to higher rates of depression and anxiety in young adulthood.Design Seven wave cohort study over six years.Setting 44 schools in the Australian state of Victoria.Participants A statewide secondary school sample of 1601 students aged 14-15 followed for seven years.Main outcome measure Interview measure of depression and anxiety (revised clinical interview schedule) at wave 7.Results Some 60% of participants had used cannabis by the age of 20; 7% were daily users at that point. Daily use in young women was associated with an over fivefold increase in the odds of reporting a state of depression and anxiety after adjustment for intercurrent use of other substances (odds ratio 5.6, 95% confidence interval 2.6 to 12). Weekly or more frequent cannabis use in teenagers predicted an approximately twofold increase in risk for later depression and anxiety (1.9, 1.1 to 3.3) after adjustment for potential baseline confounders. In contrast, depression and anxiety in teenagers predicted neither later weekly nor daily cannabis use.Conclusions Frequent cannabis use in teenage girls predicts later depression and anxiety, with daily users carrying the highest risk. Given recent increasing levels of cannabis use, measures to reduce frequent and heavy recreational use seem warranted.