The profile of behavioral and psychological symptoms in vascular cognitive impairment with and without dementia.
The profile of behavioral and psychological symptoms in vascular cognitive impairment with and without dementia.
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DOI：
10.4103/0972-2327.120488
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发表时间：
2013-10
影响因子：
1.7
通讯作者：
Batra A
中科院分区：
文献类型：
--
作者：
Gupta M;Dasgupta A;Khwaja GA;Chowdhury D;Patidar Y;Batra A
本研究的目的是比较血管性痴呆（VaD）和血管性认知障碍-无痴呆（VCI-ND）之间痴呆（BPSD）行为和心理症状的发生和严重程度。在缺血性卒中后至少3个月出现认知障碍且Hachinski缺血性评分≥4的连续患者被纳入研究。VaD的诊断是根据国家神经疾病和中风研究所-国际研究协会和神经科学协会对可能的VaD和VCI-ND的标准，按照加拿大健康和衰老研究的标准。分别采用临床痴呆评定量表和神经精神量表（NPI）对认知障碍严重程度和行为/心理症状进行研究。所有VaD患者和89%的VCI-ND患者至少有一例BPSD。意思是不。VaD患者的NPI总评分高于VCI-ND患者。冷漠和夜间行为障碍在VaD中更为常见和严重。BPSD在VCI-ND和VaD中都很常见。BPSD的症状在两组中相似，但在VaD中更为严重。与VCI-ND相比，BPSD在VaD中的净负担更高。
The objective of this study was to compare the occurrence and severity of behavioral and psychological symptoms of dementia (BPSD) between vascular dementia (VaD) and vascular cognitive impairment-no dementia (VCI-ND). Consecutive patients presenting with cognitive impairment at least 3 months after an ischemic stroke and with a Hachinski Ischemic Score ≥4 were included. VaD was diagnosed as per National Institute of Neurological Disorders and Stroke – Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria for probable VaD and VCI-ND on the lines of the Canadian study of health and aging. The severity of cognitive impairment and the behavioral/psychological symptoms were studied by means of the clinical dementia rating scale and the neuropsychiatric inventory (NPI) respectively. All patients with VaD and 89% of those with VCI-ND had at least one BPSD. The mean no. of symptoms per patient and the total NPI scores were higher in VaD than in VCI-ND. Apathy and night-time behavior disturbances were significantly more common and severe in VaD. BPSD are very common both in VCI-ND and in VaD. The profile of BPSD is similar in both groups, albeit more severe in VaD. The net burden of BPSD is higher in VaD as compared to VCI-ND.