Serum Androgen Levels in Elite Female Athletes
Serum Androgen Levels in Elite Female Athletes
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DOI：
10.1210/jc.2014-1391
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发表时间：
2014-11-01
影响因子：
5.8
通讯作者：
Ritzen, Martin
中科院分区：
文献类型：
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作者：
Bermon, Stephane;Garnier, Pierre Yves;Ritzen, Martin
目的：在实施运动员生物护照的血液类固醇模块之前，我们测量了大量高水平女性运动员的血清雄激素水平以及生化高雄激素血症和一些性发育障碍（DSD）的患病率。方法和结果：对849名优秀女运动员进行血清T、硫酸脱氢表雄酮、雄烯二酮、SHBG、促性腺激素采用液相色谱-质谱高分辨或免疫分析法测定。计算游离T。采样时间，年龄和类型的运动项目只有一个小的影响T浓度，而种族没有。在85.5%的未使用口服避孕药的运动员中，717名运动员中有168名运动员患有少或闭经。口服避孕药者血清雄激素和促性腺激素水平最低，SHBG水平最高。在从我们的人群中删除五名服用兴奋剂的运动员和五名DSD女性后，中位T和游离T值接近久坐不动的年轻女性。T浓度的第99百分位数计算为3.08 nmol/L，低于用于雄激素敏感性正常的高雄激素女性竞争资格的10 nmol/L阈值。高雄激素46 XY DSD在我们的运动人群的患病率约为7每1000人，这是140倍高于预期在一般population.Conclusion：这是第一个研究建立规范的血清雄激素值在优秀女运动员，同时考虑到可能的影响，月经状况，口服避孕药的使用，类型的体育赛事，和种族。这些研究结果应有助于制定运动员生物护照的血液类固醇模块，并完善更多基于证据的公平政策和建议，有关女运动员高雄激素血症。
Objective: Prior to the implementation of the blood steroidal module of the Athlete Biological Passport, we measured the serum androgen levels among a large population of high-level female athletes as well as the prevalence of biochemical hyperandrogenism and some disorders of sex development (DSD).Methods and Results: In 849 elite female athletes, serum T, dehydroepiandrosterone sulphate, androstenedione, SHBG, and gonadotrophins were measured by liquid chromatography-mass spectrometry high resolution or immunoassay. Free T was calculated. The sampling hour, age, and type of athletic event only had a small influence on T concentration, whereas ethnicity had not. Among the 85.5% that did not use oral contraceptives, 168 of 717 athletes were oligo-or amenorrhoic. The oral contraceptive users showed the lowest serum androgen and gonadotrophin and the highest SHBG concentrations. After having removed five doped athletes and five DSD women from our population, median T and free T values were close to those reported in sedentary young women. The 99th percentile for T concentration was calculated at 3.08 nmol/L, which is below the 10 nmol/L threshold used for competition eligibility of hyperandrogenic women with normal androgen sensitivity. Prevalence of hyperandrogenic 46 XY DSD in our athletic population is approximately 7 per 1000, which is 140 times higher than expected in the general population.Conclusion: This is the first study to establish normative serum androgens values in elite female athletes, while taking into account the possible influence of menstrual status, oral contraceptive use, type of athletic event, and ethnicity. These findings should help to develop the blood steroidal module of the Athlete Biological Passport and to refine more evidence-based fair policies and recommendations concerning hyperandrogenism in female athletes.