Lewis base catalyzed synthesis of multisubstituted 4-sulfonyl-1H-pyrazole involving a novel 1,3-sulfonyl shift.
Lewis base catalyzed synthesis of multisubstituted 4-sulfonyl-1H-pyrazole involving a novel 1,3-sulfonyl shift.
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DOI：
10.1021/ol401818m
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发表时间：
2013-08
期刊：
影响因子：
5.2
通讯作者：
Yu Zhu;Wen-Ting Lu;Hong‐Chao Sun;Zhuang-Ping Zhan
中科院分区：
文献类型：
--
作者：
Yu Zhu;Wen-Ting Lu;Hong‐Chao Sun;Zhuang-Ping Zhan
以n -丙基磺酰腙衍生物为原料，制备了高取代的4-磺酰- 1h -吡唑。烯丙基磺酰胺的形成和1,3-磺酰基的转变是这一转变的关键步骤。
A facile synthesis of highly substituted 4-sulfonyl-1H-pyrazoles from N-propargylic sulfonylhydrazone derivatives has been developed. Allenic sulfonamide formation and 1,3-sulfonyl shift were established to be the critical steps of this transformation.