Magnesium sulphate infusion is not effective on discomfort or emergence phenomenon in paediatric adenoidectomy/tonsillectomy
Magnesium sulphate infusion is not effective on discomfort or emergence phenomenon in paediatric adenoidectomy/tonsillectomy
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DOI：
10.1016/j.ijporl.2010.09.004
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发表时间：
2010-12-01
影响因子：
1.5
通讯作者：
Tahran, Filiz Datli
中科院分区：
文献类型：
--
作者：
Apan, Alparslan;Aykac, Esra;Tahran, Filiz Datli
目的：进行这项研究，以评估可能的影响，硫酸镁，具有镇静和镇痛性能七氟烷诱导的出现激越的儿科患者进行腺样体切除术，或不扁桃体tomenty.Methods：110名年龄在3至16岁的儿科患者被随机分配到这项研究。使用丙泊酚2-2.5 mg kg（-1）、维库溴铵0.1 mg kg（-1）和芬太尼1 μ g kg（-1）诱导麻醉，并使用1 MAC的七氟醚与35%笑气混合物维持麻醉。M组于术前10 min开始输注硫酸镁30 mg kg（-1），C组于术前10 min开始输注等量生理盐水，直至手术结束。恢复特征包括拔管时间、睁眼时间、苏醒时间和相互作用。采用改良Aldrete评分（MAS）、疼痛/不适量表和躁动评分对患者进行评价。结果：镁治疗组的睁眼时间明显更长（C组：7.7 +/- 3.5，M组：12.7 +/- 17.5分钟，p = 0.001）。M组在第60分钟的躁动评分显著较低（C组：1.3 +/- 0.7，M组：1.0 +/- 0.3，p = 0.005）。静息观察期的躁动或疼痛/不适评分相同。M组的初始MAS值较低（C组：5.0 +/- 1.9，M组：4.0 +/- 1.7，p = 0.003）。两组之间关于副作用没有显著差异。结论：硫酸镁输注对七氟醚引起的不适或出现躁动没有影响。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Objective: This study was performed to evaluate the possible influence of magnesium sulphate which has sedative and analgesic properties on sevoflurane-induced emergence agitation in paediatric patients undergoing adenoidectomy with or without tonsillectomy.Methods: One hundred and ten paediatric patients aged between 3 and 16 years were randomly allocated to the study. Propofol 2-2.5 mg kg(-1), vecuronium 0.1 mg kg(-1) and fentanyl 1 mu g kg(-1) were used for induction of anesthesia and sevoflurane at 1 MAC with nitrous oxide in oxygen (35%) mixture was administered as maintenance. Magnesium sulfate 30 mg kg(-1) in saline (20 mL) in the Group M, or equal volume of saline for controls (Group C) was started 10 min before and infused until the end of the operation. Recovery characteristics included time to extubation, eyes open, emergence and interaction. Patients were evaluated using Modified Aldrete Score (MAS), Pain/Discomfort Scale and Agitation Score. Side effects were determined during emergence and in the recovery.Results: Time to open eyes was significantly higher in the magnesium treatment group (Group C: 7.7 +/- 3.5, Group M: 12.7 +/- 17.5 min, p = 0.001). Agitation score was significantly lower in Group M at the 60th min (Group C: 1.3 +/- 0.7, Group M: 1.0 +/- 0.3, p = 0.005). Agitation or pain/discomfort scores in the resting observation periods were the same. The initial MAS value was lower in Group M (Group C: 5.0 +/- 1.9, Group M: 4.0 +/- 1.7, p = 0.003). There was no significant difference between groups regarding side effects.Conclusion: Magnesium sulphate infusion has no influence on sevoflurane-induced discomfort or emergence agitation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.