Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.
Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.
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DOI：
10.1016/j.cellimm.2016.08.016
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发表时间：
2016-11
影响因子：
4.3
通讯作者：
Satoskar AR
中科院分区：
文献类型：
--
作者：
Varikuti S;Natarajan G;Oghumu S;Sperling RH;Moretti E;Stock J;Papenfuss TL;Satoskar AR
由多诺瓦利什曼原虫引起的内脏利什曼病的结果取决于利什曼细胞Th1的募集。趋化因子受体CXCR3优先由Th1细胞表达，在感染期间对这些T细胞的迁移至关重要。在慢性VL期间，脾脏中表达cxcr3的CD4+ T细胞的存在减少，这与该器官的高寄生负担有关。因此，我们研究了小鼠中T细胞特异性表达CXCR3 （CXCR3Tg）是否会促进对VL的抵抗。L. donovani感染的CXCR3Tg小鼠脾脏中T细胞的积累比WT幼鼠（CXCR3+/+）增加。然而，CXCR3Tg小鼠的CXCR3+ T细胞CD69表达较低，这些小鼠发生的肉芽肿较少。此外，两组小鼠在感染过程中表现出相似的细胞因子谱和寄生虫负担。综上所述，尽管T细胞特异性表达CXCR3促进了L. donovani感染期间表达CXCR3的T细胞的积累，但这并没有增强对VL的抗性。
The outcome of visceral leishmaniasis, caused by parasite Leishmania donovani, depends on the recruitment of leishmanicidal Th1 cells. Chemokine receptor CXCR3, preferentially expressed by Th1 cells, is critical for migration of these T cells during infection. During chronic VL, there is a decrease in the presence of CXCR3-expressing CD4+ T cells in the spleen, which is associated with high parasitic burden in this organ. We therefore examined whether T cell-specific expression of CXCR3 in mice (CXCR3Tg) would promote resistance to VL. L. donovani infected CXCR3Tg mice showed increased accumulation of T cells in the spleens compared to WT littermates (CXCR3+/+). However, CXCR3+ T cells from CXCR3Tg mice showed low CD69 expression and these mice developed fewer granulomas. Additionally, both groups of mice showed similar cytokine profiles and parasitic burdens during the course of infection. In summary, although T cell-specific expression of CXCR3 promoted the accumulation of CXCR3-expressing T cells during L. donovani infection, this did not enhance resistance to VL.
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影响因子：
13.3
作者：
McGwire, B. S.;Satoskar, A. R.
通讯作者：
Satoskar, A. R.
影响因子：
6.7
作者：
Cohen SB;Maurer KJ;Egan CE;Oghumu S;Satoskar AR;Denkers EY
通讯作者：
Denkers EY
影响因子：
5.4
作者：
Rosas, LE;Barbi, J;Satoskar, AR
通讯作者：
Satoskar, AR
影响因子：
6.4
作者：
Barbi, Joseph;Oghumu, Steve;Satoskar, Abhay R.
通讯作者：
Satoskar, Abhay R.
影响因子：
4.4
作者：
Barbi, Joseph;Brombacher, Frank;Satoskar, Abhay R.
通讯作者：
Satoskar, Abhay R.