Disinfection using ultraviolet radiation as an antimicrobial agent: a review and synthesis of mechanisms and concerns.
Disinfection using ultraviolet radiation as an antimicrobial agent: a review and synthesis of mechanisms and concerns.
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使用紫外线辐射作为抗菌剂进行消毒：机制和关注点的回顾和综合。
DOI：
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发表时间：
2006
影响因子：
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通讯作者：
Carla Moffatt
中科院分区：
文献类型：
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作者：
L. G. Piluso;Carla Moffatt
如果没有有效的消毒方法，就无法维持敏感医疗机构中微生物的控制。最近，微生物对包括抗生素在内的常见化学制剂的耐药性不断增加，需要实施新的消毒方法，而这种卫生做法至关重要。制药商和许多相关行业也需要有效的消毒和卫生策略。因此，建立了指导和维持有效微生物控制的标准实践。这些实践充分利用了对生物过程的透彻理解并操纵它们以保持有价值产品的质量和安全。大多数生物过程都与其周围环境保持着微妙的平衡。当消毒过程中环境发生变化时，受损的微生物可能会通过修复直接损伤或通过产生耐药性来调整其生物过程来做出反应。除非始终如一地应用健全的消毒程序，否则可能会人为选择能够利用多种抗性标记的新环境微生物菌株。目前许多大医院正在研究和管理相关耐药性的例子，但非化学方法也受到类似的关注。在这里，我们回顾了基于紫外线的消毒方法的使用、其生物学基础以及可能出现的一些潜在的脱敏问题。最后，我们提出了一些研究和实际解决这些影响的方法。
Control of microbes in sensitive health care settings cannot be maintained without effective disinfection methods. Recently, increasing microbial resistance to common chemical agents, including antibiotics, has required the implementation of new approaches to disinfection where such sanitary practices are critical. Pharmaceutical manufacturers and many interrelated industries also have a need for effective disinfection and sanitation strategies. As a result, standard practices that direct and maintain effective microbial controls are established. These practices exploit a thorough understanding of biological processes and manipulate them to preserve the quality and safety of a valuable product. Most biological processes are delicately balanced with their surroundings, or environment. When changes are made to the environment during disinfection, damaged microbes may respond by repairing the immediate damage or by adapting their biological processes through developing a resistance. Unless sound disinfection procedures are consistently applied, new strains of environmental microbes that can utilize multiple resistance markers may be artificially selected. Examples of related drug resistance are currently being studied and managed in many large hospitals, but non-chemical methods are also subject to similar concerns. Here, we review the use of ultraviolet-based disinfection practices, the biological basis for them, and some potential desensitization issues that may develop. Finally, we suggest some approaches to study and practically address these effects.