Lower expression of sialic acid receptors in the cecum of silky fowl (Gallus gallus domesticus Brisson) compared to white leghorn
Lower expression of sialic acid receptors in the cecum of silky fowl (Gallus gallus domesticus Brisson) compared to white leghorn
复制标题
与白来航相比，丝鸡（Gallus gallus Domesticus Brisson）盲肠中唾液酸受体的表达较低
DOI：
10.3382/ps/pew065
复制
发表时间：
2016-06-01
期刊：
影响因子：
4.4
通讯作者：
Deng, Xuemei
中科院分区：
文献类型：
--
作者：
Han, Deping;Hu, Yanxin;Deng, Xuemei
禽流感病毒近年来受到越来越多的关注，因为它有可能与人类病毒重组。靶细胞上唾液酸受体的分布是不同物种对流感病毒感染易感性的决定因素。本研究比较了乌骨鸡和白来航鸡呼吸道和胃肠道唾液酸受体的分布。结果表明，唾液酸-α-2，3-半乳糖受体和唾液酸-α-6-半乳糖受体在乌骨鸡和白来航鸡中均有表达，但乌骨鸡的阳性细胞较少，盲肠中的阳性细胞数差异显著。唾液酸受体丰度低可能是由于乌骨鸡盲肠中CD3和F4/80免疫细胞丰度低所致。
Avian influenza virus has received increasing attention in recent years because of the potential for recombination with the human virus. Distributions of sialic acid receptors on target cells are determinants of the susceptibilities of different species to influenza virus infection. In this study, the distribution of sialic acid receptors in the respiratory and gastrointestinal tracts of Silky Fowl and White Leghorn chickens were compared. The results showed that sialic acid-alpha-2,3-galactose receptors and sialic acid-alpha 6-galactose receptors were both observed in Silky Fowl and White Leghorn, but fewer positive cells were detected in Silky Fowl with significant difference in the cecum. The lower abundance of sialic acid receptors likely results from the lower abundance of CD3 and F4/80 immune cells in the cecum of Silky Fowl.