Complete genome sequence of the apicomplexan, Cryptosporidium parvum
Complete genome sequence of the apicomplexan, Cryptosporidium parvum
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DOI：
10.1126/science.1094786
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发表时间：
2004-04-16
期刊：
影响因子：
56.9
通讯作者：
Kapur, V
中科院分区：
文献类型：
--
作者：
Abrahamsen, MS;Templeton, TJ;Kapur, V
顶复门隐孢子虫是一种肠道寄生虫，影响健康的人类和动物，并导致免疫功能低下的个体，如艾滋病患者的无情感染。我们报道了C. parvum，II型分离物。基因组分析确定了极其简化的代谢途径和对宿主营养的依赖。与疟原虫和弓形虫相反，该寄生虫缺乏顶质体及其基因组，并且具有已丢失其基因组的退化的顶质体。还检测到几种新型的细胞表面和分泌蛋白，其在宿主相互作用和发病机制中具有潜在作用。阐明核心代谢，包括与细菌和植物对应物高度相似的酶，为药物开发开辟了新的途径。
The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.