Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control.
Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control.
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DOI：
10.1016/j.bbagen.2009.03.013
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发表时间：
2009-09
影响因子：
3
通讯作者：
Lelievre, Sophie A.
中科院分区：
文献类型：
--
作者：
Lelievre, Sophie A.
关键词：
组蛋白的翻译后修饰、ATP依赖性染色质重塑和DNA甲基化是相互关联的核机制，其最终导致进行表观遗传基因表达控制所必需的染色质结构的变化。组织分化的特征在于与获得确定的组织结构和功能相关的特定基因表达谱。组织分化的关键因素，如细胞外刺激，粘附和细胞形状特性，以及转录因子都有助于基因表达的调节，因此，很可能会影响表观遗传基因表达控制的核机制。在这篇综述中，我们分析了这些元素如何修改染色质结构的分层方式，通过作用于核机器。我们讨论如何mechanotransduction通过结构连续的细胞和生化信号细胞核整合，提供一个全面的控制基因表达。核组织在这种控制中的作用是突出的，与介绍分化诱导的核结构和概念的核组织作为调制器的响应传入的信号。
Post-translational modification of histones, ATP-dependent chromatin remodeling, and DNA methylation are interconnected nuclear mechanisms that ultimately lead to the changes in chromatin structure necessary to carry out epigenetic gene expression control. Tissue differentiation is characterized by a specific gene expression profile in association with the acquisition of a defined tissue architecture and function. Elements critical for tissue differentiation, like extracellular stimuli, adhesion and cell shape properties, and transcription factors all contribute to the modulation of gene expression and thus, are likely to impinge on the nuclear mechanisms of epigenetic gene expression control. In this review, we analyze how these elements modify chromatin structure in a hierarchical manner by acting on the nuclear machinery. We discuss how mechanotransduction via the structural continuum of the cell and biochemical signaling to the cell nucleus integrate to provide a comprehensive control of gene expression. The role of nuclear organization in this control is highlighted, with a presentation of differentiation-induced nuclear structure and the concept of nuclear organization as a modulator of the response to incoming signals.
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影响因子：
4
作者：
BOULIKAS, T;KONG, CF
通讯作者：
KONG, CF
DOI：
10.1083/jcb.200405004
发表时间：
2004-09-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Engler AJ;Griffin MA;Sen S;Bönnemann CG;Sweeney HL;Discher DE
通讯作者：
Discher DE
影响因子：
4
作者：
Fatemi, Mehrnaz;Wade, Paul A.
通讯作者：
Wade, Paul A.
影响因子：
3.7
作者：
Figueroa ME;Reimers M;Thompson RF;Ye K;Li Y;Selzer RR;Fridriksson J;Paietta E;Wiernik P;Green RD;Greally JM;Melnick A
通讯作者：
Melnick A
影响因子：
7.8
作者：
Crisp, M;Liu, Q;Hodzic, D
通讯作者：
Hodzic, D