Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase.
Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase.
复制标题
自然经期的女性在激素水平较低的时期表现出比口服避孕药使用者更低的心血管压力反射敏感性。
DOI：
10.1113/ep091394
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发表时间：
2023
影响因子：
2.7
通讯作者：
Ranadive,SushantM
中科院分区：
文献类型：
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作者：
Mascone,SaraE;Jacob,DainW;Eagan,LaurenE;Harper,JenniferL;Limberg,JacquelineK;Ranadive,SushantM
本研究评估了自然避孕妇女（NAT妇女）和口服激素避孕药妇女（OCP妇女）在月经/避孕药周期中的心迷走神经压力反射敏感性（BRS）。在21名NAT女性（23 ± 4岁）和22名OCP女性（23 ± 3岁）中，在低激素（早期卵泡/安慰剂药丸）和高激素（晚期卵泡至早期黄体/活性药丸）阶段评估了心迷走神经BRS和雌二醇和孕酮的循环浓度。在低激素阶段，NAT女性的心迷走神经BRS上升、下降和平均增益较低（15.6 ± 8.3、15.2 ± 6.1和15.1 ± 7.1）ms/mmHg（24.7 ± 9.4、22.9 ± 8.0和23.0 ± 8.0 ms/mmHg）（P= 0.003，P = 0.002，P = 0.003），高雌激素水平（R2= 0.15，P = 0.024），而不是孕酮（R2= 0.06，P = 0.18），浓度预测较低的BRS平均增益。在高激素阶段，高孕酮浓度预测低BRS平均增重（R2= 0.12，P = 0.024）。多变量回归模型显示，当调整激素浓度后，组（NAT或OCP）是低激素阶段心迷走神经BRS平均增益的显著预测因子（R2= 0.36，P = 0.0044）。在高激素阶段，多元回归模型不显著（P> 0.05）。总之，在月经/避孕药周期的低激素阶段，NAT患者的心迷走神经BRS低于OCP患者，可能与较高的雌激素浓度有关。相反，在月经/OCP周期的高激素阶段，较高的孕酮浓度预测较低的心迷走神经BRS。
The present study evaluated cardiovagal baroreflex sensitivity (BRS) across the menstrual/pill cycle in naturally menstruating women (NAT women) and women using oral hormonal contraceptives (OCP women). In 21 NAT women (23 ± 4 years old) and 22 OCP women (23 ± 3 years old), cardiovagal BRS and circulating concentrations of estradiol and progesterone were evaluated during the lower hormone (early follicular/placebo pill) and higher hormone (late follicular to early luteal/active pill) phases. During the lower hormone phase, cardiovagal BRS up, down and mean gain were lower in NAT women (15.6 ± 8.3, 15.2 ± 6.1 and 15.1 ± 7.1 ms/mmHg) compared with OCP women (24.7 ± 9.4, 22.9 ± 8.0 and 23.0 ± 8.0 ms/mmHg) (P= 0.003,P= 0.002 andP= 0.003, respectively), and higher oestrogen (R2= 0.15,P= 0.024), but not progesterone (R2= 0.06,P= 0.18), concentrations were predictive of lower BRS mean gain. During the higher hormone phase, higher progesterone concentrations were predictive of lower BRS mean gain (R2= 0.12,P= 0.024). A multivariate regression model revealed group (NAT or OCP) to be a significant predictor of cardiovagal BRS mean gain in the lower hormone phase when hormone concentrations were adjusted for (R2= 0.36,P= 0.0044). The multivariate regression model was not significant during the higher hormone phase (P> 0.05). In summary, cardiovagal BRS is lower in NAT compared with OCP women during the lower hormone phase of the menstrual/pill cycle and might be associated with higher oestrogen concentrations. In contrast, during the higher hormone phase of the menstrual/OCP cycle, higher progesterone concentrations were predictive of lower cardiovagal BRS.