Dose-response relationships for foot and mouth disease in cattle and sheep
Dose-response relationships for foot and mouth disease in cattle and sheep
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DOI：
10.1017/s0950268801006446
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发表时间：
2002-04-01
影响因子：
4.2
通讯作者：
Clancy, D
中科院分区：
文献类型：
--
作者：
French, NP;Kelly, L;Clancy, D
通过对实验数据拟合剂量反应模型，研究了口蹄疫病毒吸入剂量与感染和疾病结局之间的关系。使用最大似然法和贝叶斯法估计指数和β-泊松模型的参数。单次吸入TCID 50的中位感染概率估计为0.031，牛的95%贝叶斯可信区间（CI）为0.018-0.052，绵羊为0.045（CI = 0.024-0.080）。这些估计被用来构建剂量-反应曲线和不确定性分布，用于定量风险评估。
The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0.031 with 95% Bayesian credibility intervals (CI) of 0.018-0.052 for cattle, and 0.045 (CI = 0.024-0.080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.