Significance of C-reactive protein and transcranial Doppler in cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Significance of C-reactive protein and transcranial Doppler in cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
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C反应性蛋白和经颅多普勒在大障碍性蛛网膜下腔出血后的脑血管痉挛中的重要性。
DOI：
10.3340/jkns.2013.54.4.289
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发表时间：
2013-10
影响因子：
1.6
通讯作者：
Kang H
中科院分区：
文献类型：
--
作者：
Hwang SH;Park YS;Kwon JT;Nam TK;Hwang SN;Kang H
脑血管痉挛是蛛网膜下腔出血（aSAH）的常见并发症，具有潜在的破坏性。炎症过程似乎在血管痉挛的发病机制中起主要作用。C-反应蛋白（CRP）是一种高度敏感的炎症标志物。aSAH患者血清CRP水平升高。本研究的目的是评估aSAH患者血清和经颅多普勒（TCD）中CRP水平与血管痉挛发生的可能关系。从2008年11月至2011年5月，共有61例诊断为aSAH的成人患者纳入研究。记录患者的人口统计学资料、Hunt和Hess分级、Fisher分级、CT扫描、数字减影血管造影研究和每日神经系统检查。在第1、3、5、7、9、11和13天连续测量血清CRP，并在第3、5、7、9、11和13天测量TCD。所有患者均在出血性发作后24小时内接受手术或血管内治疗。血清CRP水平在术后第3天达到峰值。血管痉挛组与非血管痉挛组在第1、3、5天比较差异有统计学意义。脑血管痉挛组与非脑血管痉挛组在第3天的大脑中动脉血流速度差异有统计学意义。术后第1天CRP水平高且术后第3天TCD平均速度高的患者可能需要密切观察以监测血管痉挛的发展。
Cerebral vasospasm is a common and potentially devastating complication of aneurysmal subarachnoid hemorrhage (aSAH). Inflammatory processes seem to play a major role in the pathogenesis of vasospasm. C-reactive protein (CRP) constitutes a highly sensitive inflammatory marker. Elevation of serum CRP levels has been demonstrated in patients with aSAH. The purpose of the current study was to evaluate the possible relationship between CRP levels in the serum and transcranial Doppler (TCD) and the development of vasospasm in patients with aSAH. A total of 61 adult patients in whom aSAH was diagnosed were included in the study from November 2008 to May 2011. The patients' demographics, Hunt and Hess grade, Fisher grade, CT scans, digital subtraction angiography studies, and daily neurological examinations were recorded. Serial serum CRP measurements were obtained on days 1, 3, 5, 7, 9, 11 and 13 and TCD was measured on days 3, 5, 7, 9, 11 and 13. All patients underwent either surgical or endovascular treatment within 24 hours of their hemorrhagic attacks. Serum CRP levels peaked on the 3rd postoperative day. There were significant differences between the vasospasm group and the non-vasospasm group on the 1st, 3rd and 5th day. There were significant differences between the vasospasm group and the non-vasospasm group on the 3rd day in the mean middle cerebral artery velocities on TCD. Patients with high levels of CRP on the 1st postoperative day and high velocity of mean TCD on the 3rd postoperative day may require closer observation to monitor for the development of vasospasm.
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影响因子：
3.7
作者：
Jeon, Young-Tae;Lee, Ju-Hyun;Park, Hee-Pyoung
通讯作者：
Park, Hee-Pyoung
影响因子：
39.2
作者：
Buckley, David I.;Fu, Rongwei;Helfand, Mark
通讯作者：
Helfand, Mark
影响因子：
9.9
作者：
Elkind, M. S. V.;Luna, J. M.;Sacco, R. L.
通讯作者：
Sacco, R. L.
影响因子：
2.8
作者：
Umemoto, S;Suzuki, N;Matsuzaki, M
通讯作者：
Matsuzaki, M
影响因子：
3.5
作者：
Hansen-Schwartz, J
通讯作者：
Hansen-Schwartz, J