Fetal glucose uptake and utilization as functions of maternal glucose concentration.
Fetal glucose uptake and utilization as functions of maternal glucose concentration.
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DOI：
10.1152/ajpendo.1984.246.3.e237
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发表时间：
1984-03
期刊：
影响因子：
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通讯作者：
William W. Hay;John W. Sparks;R. Wilkening;Frederick C. Battaglia;Giacomo Meschia
中科院分区：
文献类型：
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作者：
William W. Hay;John W. Sparks;R. Wilkening;Frederick C. Battaglia;Giacomo Meschia
在12只妊娠绵羊中进行了17项研究，以检查通过脐循环同时测量的葡萄糖摄取、胎儿葡萄糖利用（mg X min-1 X kg-1）和母体动脉葡萄糖（Gm，mg/dl）之间的关系。胎儿葡萄糖利用率通过向胎儿或母亲和胎儿输注示踪葡萄糖来测量。通过禁食母羊，Gm在62-22范围内变化。Gm的降低伴随着显著的（P <0.001）脐带吸收减少（摄取= 0.09 Gm - 0.96，r = 0.82）和胎儿利用率，通过[U-14 C]葡萄糖（利用率= 0.062Gm + 0.91，r = 0.90）或[6- 3 H]葡萄糖（利用率= 0.065Gm + 0.51，r = 0.91）。在吸收大于3 mg X min-1 X kg-1时，利用和吸收没有显著差异。在较低的摄取量，利用率并没有下降一样多的吸收。结果表明，母亲禁食降低脐吸收和胎儿利用葡萄糖，并建议胎儿葡萄糖生成增加时，外源性葡萄糖的可用性显着减少。
Seventeen studies were performed in 12 pregnant sheep to examine the relationship among simultaneously measured glucose uptake via the umbilical circulation, fetal glucose utilization (mg X min-1 X kg-1), and maternal arterial glucose (Gm, mg/dl). Fetal glucose utilization was measured by means of tracer glucose infused into the fetus or both mother and fetus. By fasting the ewe, Gm was varied in the 62-22 range. A decrease in Gm was accompanied by a significant (P less than 0.001) decrease in umbilical uptake (uptake = 0.09 Gm - 0.96, r = 0.82) and in fetal utilization, measured either by [U-14C]glucose (utilization = 0.062 Gm + 0.91, r = 0.90) or [6-3H]glucose (utilization = 0.065 Gm + 0.51, r = 0.91). At uptake greater than 3 mg X min-1 X kg-1, utilization and uptake were not significantly different. At lower uptakes, utilization did not decline as much as uptake. The results demonstrate that maternal fasting decreases both the umbilical uptake and the fetal utilization of glucose and suggest that fetal glucogenesis increases when the availability of exogenous glucose is markedly reduced.