Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1.
Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1.
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人类免疫缺陷病毒 1 型感染患者神经梅毒的诊断。
DOI：
10.1093/infdis/174.1.219
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Jacobson,MA
中科院分区：
文献类型：
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作者：
Marra,CM;Gary,DW;Kuypers,J;Jacobson,MA
在人类免疫缺陷病毒1型（HIV）感染者中，神经梅毒的诊断可能特别困难。应用聚合酶链反应（PCR）检测81例HIV感染者脑脊液（CSF）中梅毒螺旋体DNA。2例患者经血清反应性及脑脊液VDRL试验确诊为神经梅毒。苍白球DNA在任何样品中均未被一致地检测到，即使CSF-VDRL是反应性的。脑脊液细胞增多、蛋白质升高或葡萄糖浓度降低与接触或感染旋毛虫的病史无显著相关性。苍白球根据常规脑脊液检查和T. pallidumPCR结果显示，HIV感染者中未发现神经梅毒的证据。CSF上的苍白球DNA PCR并未提供比传统CSF分析更多的信息。需要进一步的研究，以确定该测试在诊断和治疗神经梅毒的效用。
Establishing the diagnosis of neurosyphilis may be particularly difficult in human immunodeficiency virus type 1 (HIV)-infected persons. Polymerase chain reaction (PCR) was used to detectTreponema pallidumDNA in cerebrospinal fluid (CSF) from 81 HIV -infected patients. On the basis of reactive serum and CSF-VDRL tests, 2 patients were diagnosed as having neurosyphilis.T. pallidumDNA was not consistently detected in any sample, even when the CSF-VDRL was reactive. CSF pleocytosis, elevated protein, or depressed glucose concentration was not significantly associated with a history of exposure to or infection withT. pallidum. On the basis of results of routine CSF measurements andT. pallidumPCR results, no evidence was found for undiagnosed neurosyphilis in HIV-infected patients.T. pallidumDNA PCR on CSF did not provide more information than conventional CSF analysis. Further study is needed to determine the utility of this test in the diagnosis and treatment of neurosyphilis.