Factor XIII Val34Leu variant and the risk of myocardial infarction
Factor XIII Val34Leu variant and the risk of myocardial infarction
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第 XIII 因子 Val34Leu 变异与心肌梗塞的风险
DOI：
10.1160/th06-09-0517
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发表时间：
2007
影响因子：
6.7
通讯作者：
P. Wells
中科院分区：
文献类型：
--
作者：
M. Shafey;Josdalyne L. Anderson;D. Scarvelis;S. Doucette;F. Gagnon;P. Wells
遗传因素被认为与急性心肌梗死（AMI）的发病机制有关。因子XIII （FXIII）的一种常见变体FXIII Val34Leu可能对AMI的发生有保护作用，但各种研究显示出相互矛盾的结果。我们进行了一项荟萃分析，以确定FXIII Val34Leu变异是否与AMI风险降低相关。我们回顾了195篇文章，并选择了12项病例对照研究。我们纳入了客观诊断ami （WHO标准）患者的研究，前提是FXIII Val34Leu基因分型数据可用。纳入决策、质量评估和数据提取由两名审稿人进行。假设Leu等位基因具有保护作用，我们以Val/Val基因型作为参照组进行了三项分析。确定合并优势比（OR）及其95%置信区间（95% CI）。在合并之前，使用i2统计量进行异质性检验。这些研究共纳入8,743例患者，其中3,663例为AMI患者，5,080例为健康对照。采用随机效应方法，Leu/Val基因型单独（OR 0.79, 95% CI 0.68-0.93）和Leu/Val和Leu/Leu基因型联合（OR 0.79, 95% CI 0.66-0.93）均有保护作用。单独使用Leu/Leu基因型也有保护作用（无统计学意义：OR 0.83, 95% CI 0.61-1.12），可能是由于该基因型的频率较低。这些结果表明，因子XIII Leu等位基因与对AMI的适度保护作用之间存在关联，并可能为分析心肌梗死的易感性提供有用的信息。
Summary Genetic factors are thought to contribute to the pathogenesis of acute myocardial infarction (AMI).A common variant of factor XIII (FXIII), FXIII Val34Leu, may be protective against developing an AMI, but various studies show conflicting results. We performed a meta-analysis to determine whether the FXIII Val34Leu variant is associated with a decreased risk of AMI. One hundred ninety-five articles were reviewed and 12 case-control studies were selected. We included studies involving patients with objectively diagnosed AMIs (WHO criteria), provided that FXIII Val34Leu genotyping data were available. Inclusion decisions, quality assessment, and data extraction were conducted by two reviewers. Hypothesizing that the Leu allele was protective, we performed three analyses with the Val/Val genotype as the reference group. Pooled odds ratios (OR) and their 95% confidence intervals (95% CI) were determined. Prior to pooling, heterogeneity testing was performed using the I 2 statistic. These studies included a total of 8,743 patients, of which 3,663 were AMI patients and 5,080 were healthy controls. Using the random effects methods, protective effects were seen with the Leu/Val genotype alone (OR 0.79, 95% CI 0.68–0.93) and with Leu/Val and Leu/Leu genotypes combined (OR 0.79, 95% CI 0.66–0.93).There was also a protective effect with the Leu/Leu genotype alone, (not statistically significant: OR 0.83, 95% CI 0.61–1.12), likely due to the low frequency of this genotype. These results suggest that there is an association between the factor XIII Leu allele and a modest protective effect against AMI and may provide useful information in profiling susceptibility to myocardial infarction.
人类因子XIII：纤维蛋白稳定因子。
DOI：
--
发表时间：
1980
期刊：
Progress in hemostasis and thrombosis
影响因子：
--
作者：
Lorand,L;Losowsky,MS;Miloszewski,KJ
通讯作者：
Miloszewski,KJ