No evidence for simian virus 40 DNA sequences in malignant non‐Hodgkin lymphomas
No evidence for simian virus 40 DNA sequences in malignant non‐Hodgkin lymphomas
复制标题
没有证据表明恶性非霍奇金淋巴瘤中存在猿猴病毒 40 DNA 序列
DOI：
--
复制
发表时间：
2006
影响因子：
6.4
通讯作者：
G. Dölken
中科院分区：
文献类型：
--
作者：
F. Schüler;Sandra C. Dölken;C. Hirt;M. Dölken;R. Mentel;L. Gürtler;G. Dölken
DNA sequences coding for simian virus 40 (SV40) large T antigen have been detected at different frequencies in human non‐Hodgkin's lymphomas (NHL) by PCR techniques as well as immunohistochemistry. A highly sensitive quantitative real‐time PCR specific for a sequence of SV40 large T antigen was established to test whether SV40 DNA is present in malignant lymphomas of German patients. Thirty‐three lymph node samples obtained from 27 patients with NHL and 6 patients with Hodgkin's disease (HD) were tested in addition to 48 samples of peripheral blood mononuclear cells (PBMNC) from patients with NHL containing between 0.1% and >90% circulating lymphoma cells determined by PCR. Fourteen lymph nodes obtained from patients with other diseases than malignant lymphomas and 47 PBMNC samples from healthy volunteers served as controls. All samples from patients with malignant lymphomas and all controls were negative for SV40 DNA by quantitative real‐time. In contrast, EBV‐DNA could be detected in 29 of 46 DNA preparations isolated from lymph nodes (63%) and in 20 of 47 DNA preparations from PBMNC. EBV‐positive samples contained between 5 and 80,000 EBV copies per 100,000 cells. Our results do not support the hypothesis that SV40 plays a major role in the etiology of malignant lymphomas and, in addition, they exclude a clonal SV 40 infection of malignant lymphoma cells in all samples investigated. © 2005 Wiley‐Liss, Inc.
登录
查看更多内容
JC 病毒、BK 病毒、猿猴病毒 40 的血清抗体，以及发生成人星形细胞脑肿瘤的风险。
DOI：
--
发表时间：
2003
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Rollison,DanaEM;Helzlsouer,KathyJ;Alberg,AnthonyJ;Hoffman,Sandra;Hou,Jean;Daniel,Richard;Shah,KeertiV;Major,EugeneO
通讯作者：
Major,EugeneO
一项多机构研究证实了猿病毒 40 在人类恶性间皮瘤中的存在和表达。
DOI：
--
发表时间：
1998
期刊：
Cancer research.
影响因子：
--
作者：
Testa,JR;Carbone,M;Hirvonen,A;Khalili,K;Krynska,B;Linnainmaa,K;Pooley,FD;Rizzo,P;Rusch,V;Xiao,GH
通讯作者：
Xiao,GH
用于实时 PCR 定量急性淋巴细胞白血病残留疾病的免疫球蛋白重链共有探针。
影响因子：
20.3
作者：
Donovan,JW;Ladetto,M;Zou,G;Neuberg,D;Poor,C;Bowers,D;Gribben,JG
通讯作者：
Gribben,JG
猿猴病毒 40 存在于大多数美国人类间皮瘤中，但很少存在于非霍奇金淋巴瘤中。
影响因子：
9.6
作者：
Rizzo,P;Carbone,M;Fisher,SG;Matker,C;Swinnen,LJ;Powers,A;DiResta,I;Alkan,S;Pass,HI;Fisher,RI
通讯作者：
Fisher,RI