Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique.
Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique.
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发表时间：
1992-04
期刊：
影响因子：
11.2
通讯作者：
Clifford W. Welsch
中科院分区：
文献类型：
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作者：
Clifford W. Welsch
膳食脂肪可显著影响小鼠和大鼠的乳腺肿瘤发生，这一点已得到明确证实。本文的目的是回顾和批评这种有趣的和潜在的重要关系。本文就膳食脂肪的种类和数量与热量在啮齿类动物乳腺肿瘤发生和转移中的作用进行综述。此外，研究了膳食脂肪对免疫缺陷小鼠中人乳腺癌移植物发展的影响。本综述中引用的大量研究为膳食脂肪和/或热量消耗与人群乳腺癌发展之间的潜在重要关系提供了令人信服的生物学基础。
That dietary fat can significantly affect mammary tumorigenesis in mice and rats has been clearly established. The purpose of this communication is to review and critique this interesting and potentially important relationship. This review focuses on the relationship between the amount and type of dietary fat and the role of calories in rodent mammary tumor development and metastasis. Additionally, the influence of dietary fat on development of human breast carcinoma transplants in immunodeficient mice is examined. The numerous studies cited in this review provide a compelling biological foundation for a potentially important relationship between dietary fat and/or calorie consumption and breast carcinoma development in human populations.