Physical activity, motor function, and white matter hyperintensity burden in healthy older adults
Physical activity, motor function, and white matter hyperintensity burden in healthy older adults
复制标题
DOI：
10.1212/wnl.0000000000001417
复制
发表时间：
2015-03-31
期刊：
影响因子：
9.9
通讯作者：
Buchman, Aron S.
中科院分区：
文献类型：
--
作者：
Fleischman, Debra A.;Yang, Jingyun;Buchman, Aron S.
目的：为了验证这一假设，即体力活动修改之间的关联白色物质高强度（WMH）的负担和运动功能的健康老年人无dementions.Methods：总的日常活动（运动和非运动体力活动）进行了测量，长达11天的活动记录（Actial;飞利浦Respironics，弯曲，OR）在167名老年人无痴呆症参与拉什记忆和衰老项目。将11项运动表现总结为先前描述的整体运动评分。WMH体积表示为颅内体积的百分比。线性回归模型，调整了年龄，教育和性别，总WMH体积作为预测因子和全球运动评分作为结果。每日总体力活动及其与WMH体积的相互作用的条款，然后添加到model.Results：较高的WMH负担与较低的运动功能（p = 0.006），和每日总活动与运动功能呈正相关（p = 0.002）。每日总活动量改变了WMH与运动功能之间的相关性（p = 0.007）。WMH负荷与高活动量（第90百分位数）人群的运动功能无关。相比之下，较高的WMH负担仍然与平均（第50百分位数;估计值=-0.304，斜率= -0.133）和低（第10百分位数;估计值=-1.793，斜率= -0.241）activity.Conclusions的人较低的运动功能：较高水平的体力活动可能会减少WMH负担对运动功能的影响在健康的老年人。
Objective: To test the hypothesis that physical activity modifies the association between white matter hyperintensity (WMH) burden and motor function in healthy older persons without dementia.Methods: Total daily activity (exercise and nonexercise physical activity) was measured for up to 11 days with actigraphy (Actical; Philips Respironics, Bend, OR) in 167 older adults without dementia participating in the Rush Memory and Aging Project. Eleven motor performances were summarized into a previously described global motor score. WMH volume was expressed as percent of intracranial volume. Linear regression models, adjusted for age, education, and sex, were performed with total WMH volume as the predictor and global motor score as the outcome. Terms for total daily physical activity and its interaction withWMH volume were then added to the model.Results: Higher WMH burden was associated with lower motor function (p = 0.006), and total daily activity was positively associated with motor function (p = 0.002). Total daily activity modified the association between WMH and motor function (p = 0.007). WMH burden was not associated with motor function in persons with high activity (90th percentile). By contrast, higher WMH burden remained associated with lower motor function in persons with average (50th percentile; estimate = -0.304, slope = -0.133) and low (10th percentile; estimate = -1.793, slope = -0.241) activity.Conclusions: Higher levels of physical activity may reduce the effect of WMH burden on motor function in healthy older adults.