Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.
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DOI:
10.1016/j.ccr.2011.10.005
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发表时间:
2011-10-18
期刊:
影响因子:
50.3
通讯作者:
Brugarolas J
Brugarolas J
中科院分区:
医学1区
文献类型:
--
作者:
Kinch L;Grishin NV;Brugarolas J

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Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH-deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.
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