Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese
Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese
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DOI：
10.1111/j.1530-0277.1996.tb01080.x
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发表时间：
1996-05-01
影响因子：
3.2
通讯作者：
Hayashida, M
中科院分区：
文献类型：
--
作者：
Higuchi, S;Matsushita, S;Hayashida, M
在 451 名日本人中研究了乙醇脱氢酶 2 (ADH2) 和线粒体醛脱氢酶 (ALDH2) 基因型对饮酒行为的影响。尽管 ALDH2*2 等位基因对饮酒量以及饮酒问题具有显着的抑制作用，但 ADH2 基因型与男性或女性整体饮酒模式之间的明显关联尚未得到证实。然而，根据久里浜酒精中毒筛查测试，被分类为酗酒的日本男性中 ADH2*2 等位基因的频率显着低于非酗酒男性。这些结果证实了之前的一项研究，该研究揭示了住院的日本酗酒者中 ADH2*2 等位基因频率显着低于普通人群。总之，这些研究表明 ALDH2*2 等位基因对饮酒行为具有抑制作用，无论饮酒量如何，而 ADH2 多态性的作用仅在饮酒量较高的个体（例如酗酒者）中才变得明显。
The effects of the genotype of alcohol dehydrogenase-2 (ADH2) and mitochondrial aldehyde dehydrogenase (ALDH2) on drinking behavior were investigated in a population of 451 Japanese. Although the ALDH2*2 allele had a significant inhibitory effect on alcohol consumption, hence on drinking problems, the apparent association was not confirmed between ADH2 genotype and overall drinking patterns for either males or females. However, the frequency of the ADH2*2 allele was significantly lower in male Japanese classified as alcoholic on the basis of the Kurihama Alcoholism Screening Test than in nonalcoholic males. These results corroborate a previous study that revealed a significantly lower ADH2*2 allele frequency in hospitalized Japanese alcoholics than in the general population. Together, these studies suggest that the ALDH2*2 allele has an inhibitory effect on drinking behavior, irrespective of the level of alcohol consumption, whereas the effect of the ADH2 polymorphism only becomes apparent in individuals with higher alcohol consumption, such as alcoholics.