Pargamicin a, a novel cyclic peptide antibiotic from Amycolatopsis sp.
Pargamicin a, a novel cyclic peptide antibiotic from Amycolatopsis sp.
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DOI：
10.1038/ja.2008.54
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Akamatsu, Yuzuru
中科院分区：
文献类型：
--
作者：
Igarashi, Masayuki;Sawa, Ryuichi;Akamatsu, Yuzuru
从放线菌菌株的培养液中分离出一种新型环肽抗生素帕加霉素 A。产生的生物体被命名为 ML1-hF4，被鉴定为无枝酸菌属的成员。通过各种光谱分析，帕加霉素 A 被鉴定为一种含有哌嗪酸的新型环状六肽抗生素。 Pargamicin A 对金黄色葡萄球菌菌株（包括 MRSA）和粪肠球菌/粪肠球菌菌株（包括 VRE）表现出有效的抗菌活性。
A novel cyclic peptide antibiotic, pargamicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated ML1-hF4, was identified as a member of the genus Amycolatopsis. Pargamicin A was identified as a novel cyclic hexapeptide antibiotic containing piperazic acid by various spectroscopic analyses. Pargamicin A showed potent antibacterial activity against Staphylococcus aureus strains including MRSA and Enterococcus faecalis/faecium strains including VRE.