Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies.
Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies.
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通过每月分析 HCV RNA 和抗体对血液透析患者丙型肝炎病毒感染进行前瞻性研究。
DOI：
10.1139/w03-065
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发表时间：
2003
影响因子：
2.8
通讯作者：
C. Granato
中科院分区：
文献类型：
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作者：
R. Moreira;J. Pinho;Jorge Fares;I. Oba;M. Cardoso;C. Saraceni;C. Granato
本研究的目的是(i)评估巴西圣保罗两个不同中心血液透析患者丙型肝炎病毒（HCV）感染的患病率和发病率，（ii）确定通过血清学或PCR检测这些患者中HCV感染所需的时间，（iii）确定丙氨酸转氨酶检测作为HCV感染标志物的重要性，以及（iv）确定该人群中的HCV基因型。对281例住院血液透析患者每月采集血清样本，为期1年。281例患者中，41例（14.6%）HCV阳性；在这项研究中，6例患者血清转化（发生率= 3.1/1000人月）。在1.8%（5/281）的病例中，在抗体出现前（长达5个月）检测到RNA，在1.1%（3/281）的病例中，RNA是HCV感染的唯一标志物。基因型分别为1a、1b、3a和4a。基因型4a的存在值得注意，因为它在巴西是一种罕见的基因型。这些数据指出了巴西血液透析中心HCV感染的高患病率和发病率，并表明常规PCR是提高血液透析患者中HCV携带者检测的基础。
The aims of this study were to (i) evaluate the prevalence and the incidence of hepatitis C virus (HCV) infection in hemodialysis patients in two different centers in São Paulo (Brazil), (ii) determine the time required to detect HCV infection among these patients by serology or PCR, (iii) establish the importance of alanine aminotransferase determination as a marker of HCV infection, and (iv) identify the HCV genotypes in this population. Serum samples were collected monthly for 1 year from 281 patients admitted to hospital for hemodialysis. Out of 281 patients, 41 patients (14.6%) were HCV positive; six patients seroconverted during this study (incidence = 3.1/1000 person-month). In 1.8% (5/281) of cases, RNA was detected before the appearance of antibodies (up to 5 months), and in 1.1% (3/281) of cases, RNA was the unique marker of HCV infection. The genotypes found were 1a, 1b, 3a, and 4a. The presence of genotype 4a is noteworthy, since it is a rare genotype in Brazil. These data pointed out the high prevalence and incidence of HCV infection at hemodialysis centers in Brazil and showed that routine PCR is fundamental for improving the detection of HCV carriers among patients undergoing hemodialysis.
HCV 病毒学 30 年
DOI：
--
发表时间：
2021
期刊：
影响因子：
--
作者：
Takaji Wakita
通讯作者：
Takaji Wakita