Grid-cell representations in mental simulation
Grid-cell representations in mental simulation
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DOI：
10.7554/elife.17089
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发表时间：
2016-08-30
期刊：
影响因子：
7.7
通讯作者：
Doeller, Christian F.
中科院分区：
文献类型：
--
作者：
Bellmund, Jacob L. S.;Deuker, Lorena;Doeller, Christian F.
预测未来是大脑的一个关键主题，可能是通过对即将发生的事件的心理模拟来支持的。啮齿类动物的单细胞记录表明，空间调谐细胞能够代表随后的位置。在虚拟和想象的导航过程中，在人类内嗅皮层中观察到网格状表征。然而，到目前为止，我们还不知道在没有想象运动的情况下，网格状表征是否有助于心理模拟。参与者在一个大型虚拟现实城市中想象建筑位置之间的方向，同时接受功能磁共振成像，而不需要再次暴露在环境中。通过多体素模式分析，我们在海马旁回中提供了分辨率为30的绝对想象方向表征的证据，与头部方向系统一致。此外，我们利用网格细胞放电的六重旋转对称性来证明内嗅皮层的60周期模式相似结构。我们的发现暗示了内嗅网格系统在心理模拟和超越空间导航的未来思考中的作用。
Anticipating the future is a key motif of the brain, possibly supported by mental simulation of upcoming events. Rodent single-cell recordings suggest the ability of spatially tuned cells to represent subsequent locations. Grid-like representations have been observed in the human entorhinal cortex during virtual and imagined navigation. However, hitherto it remains unknown if grid-like representations contribute to mental simulation in the absence of imagined movement. Participants imagined directions between building locations in a large-scale virtual-reality city while undergoing fMRI without re-exposure to the environment. Using multi-voxel pattern analysis, we provide evidence for representations of absolute imagined direction at a resolution of 30 in the parahippocampal gyrus, consistent with the head-direction system. Furthermore, we capitalize on the six-fold rotational symmetry of grid-cell firing to demonstrate a 60 periodic pattern-similarity structure in the entorhinal cortex. Our findings imply a role of the entorhinal grid-system in mental simulation and future thinking beyond spatial navigation.