H2-M3-restricted memory T cells: Persistence and activation without expansion
H2-M3-restricted memory T cells: Persistence and activation without expansion
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DOI：
10.4049/jimmunol.170.4.1862
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发表时间：
2003-02-15
影响因子：
4.4
通讯作者：
Pamer, EG
中科院分区：
文献类型：
--
作者：
Kerksiek, KM;Ploss, A;Pamer, EG
H2-M3限制性T细胞比传统的MHC Ia类限制性T细胞对原发性单核细胞增多性李斯特菌感染的反应更快。再感染单核细胞增生李斯特菌，虽然诱导爆炸性增殖的H2-K-d限制性T细胞，不刺激显着扩大H2-M3限制性CTL。这些对再感染的不同反应在原发性单核细胞增生李斯特菌感染后5天内是明显的。然而，产生了H2-M3限制性记忆T细胞，并且在细胞表面记忆标志物和寿命方面与经典限制性T细胞无法区分。H2-M3-和H2-K-d-限制性记忆T细胞对再感染的早期反应是相似的，活化标志物的大小和表达增加。有趣的是，用L.单核细胞生成细胞衍生的N-甲酰肽加抗CD 40产生记忆T细胞，其在L.单核细胞增多症我们的数据表明，不同的H2-M3-和MHC类Ia限制性记忆T细胞反应反映了这些T细胞群体之间的内在差异。虽然不同的增殖程序似乎是硬连线在这些人群中，在初级L。在单核细胞增多症感染的情况下，在不同的炎症情况下，M3限制性T细胞群可以在再次暴露于Ag时保持扩增的能力。
H2-M3-restricted T cells respond more rapidly to primary Listeria monocytogenes infection than conventional MHC class Ia-restricted T cells. Reinfection with L monocytogenes, while inducing explosive proliferation of H2-K-d-restricted T cells, does not stimulate significant expansion of H2-M3-restricted CTL. These disparate responses to reinfection are apparent within 5 days of primary L monocytogenes infection. However, H2-M3-restricted memory T cells are generated, and are indistinguishable from classically restricted T cells in terms of cell surface memory markers and longevity. Early responses of H2-M3- and H2-K-d- restricted memory T cells to reinfection are similar, with increases in size and expression of activation markers. Interestingly, priming of H2-M3-restricted T cells with an L. monocytogenes-derived N-formyl peptide plus anti-CD40 generates memory T cells that expand upon re-exposure to Ag during L. monocytogenes infection. Our data indicate that disparate H2-M3- and MHC class la-restricted memory T cell responses reflect intrinsic differences between these T cell populations. Although distinct proliferative programs appear to be hardwired in these populations during primary L. monocytogenes infection, under different inflammatory circumstances M3-restricted T cell populations can maintain the ability to expand upon re-exposure to Ag.