Regulation of adherence and virulence by the Entamoeba histolytica lectin cytoplasmic domain, which contains a beta2 integrin motif.
Regulation of adherence and virulence by the Entamoeba histolytica lectin cytoplasmic domain, which contains a beta2 integrin motif.
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溶组织内阿米巴凝集素细胞质结构域（含有 β2 整联蛋白基序）对粘附和毒力的调节。
DOI：
10.1091/mbc.9.8.2069
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发表时间：
1998
影响因子：
3.3
通讯作者：
PetriJr,WA
中科院分区：
文献类型：
--
作者：
Vines,RR;Ramakrishnan,G;Rogers,JB;Lockhart,LA;Mann,BJ;PetriJr,WA
Killing of human cells by the parasiteEntamoeba histolyticarequires adherence via an amebic cell surface lectin. Lectin activity in the parasite is regulated by inside-out signaling. The lectin cytoplasmic domain has sequence identity with a region of the β2 integrin cytoplasmic tail implicated in regulation of integrin-mediated adhesion. Intracellular expression of a fusion protein containing the cytoplasmic domain of the lectin has a dominant negative effect on extracellular lectin-mediated cell adherence. Mutation of the integrin-like sequence abrogates the dominant negative effect. Amebae expressing the dominant negative mutant are less virulent in an animal model of amebiasis. These results suggest that inside-out signaling via the lectin cytoplasmic domain may control the extracellular adhesive activity of the amebic lectin and provide in vivo demonstration of the lectin’s role in virulence.
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针对溶组织内阿米巴半乳糖结合凝集素的单克隆抗体可增强粘附性。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
PetriJr,WA;Snodgrass,TL;Jackson,TF;Gathiram,V;Simjee,AE;Chadee,K;Chapman,MD
通讯作者：
Chapman,MD
溶组织内阿米巴半乳糖和 N-乙酰基-D-半乳糖胺抑制粘附凝集素的亚基结构。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
PetriJr,WA;Chapman,MD;Snodgrass,T;Mann,BJ;Broman,J;Ravdin,JI
通讯作者：
Ravdin,JI
影响因子：
3.5
作者：
Cormack, BP;Valdivia, RH;Falkow, S
通讯作者：
Falkow, S
影响因子：
64.5
作者：
Kolanus, W;Nagel, W;Seed, B
通讯作者：
Seed, B
细胞粘附的内部世界：整合素胞质结构域。
影响因子：
19
作者：
Michael J. Williams;Paul E. Hughes;T. O’Toole;M. Ginsberg
通讯作者：
M. Ginsberg