Estrogen alpha and progesterone receptor expression in the normal mammary epithelium in relation to breast cancer risk.
Estrogen alpha and progesterone receptor expression in the normal mammary epithelium in relation to breast cancer risk.
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正常乳腺上皮中雌激素α和孕激素受体的表达与乳腺癌风险相关。
DOI：
10.1002/ijc.23899
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发表时间：
2009
影响因子：
6.4
通讯作者：
Trichopoulos,Dimitrios
中科院分区：
文献类型：
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作者：
Lagiou,Pagona;Georgila,Christina;Samoli,Evangelia;Lagiou,Areti;Zourna,Pantelina;Minaki,Ploumitsa;Vassilarou,Dorothy;Papadiamandis,Ioannis;Sfikas,Constantinos;Kalapothaki,Victoria;Sekeris,ConstantineE;Trichopoulos,Dimitrios
雌激素在乳腺癌的病因学中起着核心作用，观察性研究和随机试验的结果也与黄体酮有关。这些激素在乳腺组织中的作用是通过与细胞核中的特定受体蛋白结合而发挥作用的。有人提出，正常乳腺上皮中较高的雌激素受体α表达可能会增加乳腺癌的风险。在希腊的一项研究中，我们检测了267名乳腺癌妇女和299名乳腺良性疾病妇女病理组织旁的正常乳腺组织中雌激素α和孕激素受体的表达。应用小鼠雌激素受体α和孕激素受体特异性单克隆抗体。h指数包括细胞染色的频率和强度，范围从0到300，当超过9时被认为是阳性。在绝经前妇女中，没有证据表明这两种受体的表达与乳腺癌风险有关。在绝经后妇女中，乳腺癌风险与雌激素α的表达呈负相关(优势比(OR) = 0.39；p= 0.015)和黄体酮受体（OR = 0.40;p= 0.008）。正常乳腺上皮中雌激素受体或孕激素受体的过度表达可能增加乳腺癌风险的假设并未得到我们的数据支持。相反，我们发现证据表明，这些受体的过表达可能与乳腺癌风险降低有关，这与众所周知的恶性组织中这些受体的表达与乳腺癌预后的改善有关。©2008 Wiley‐Liss, Inc。
Estrogens play a central role in the etiology of breast cancer, and results from observational studies and randomized trials have also implicated progestins. The effects of these hormones in the mammary tissue are exerted through binding with specific receptor proteins in the cell nucleus. It has been proposed that higher estrogen receptor alpha expression in the normal breast epithelium may increase breast cancer risk. In a study in Greece, we determined estrogen alpha and progesterone receptor expression in normal mammary tissue adjacent to the pathological tissue from 267 women with breast cancer and 299 women with benign breast disease. Mouse monoclonal antibodies specific for estrogen receptor alpha and progesterone receptor were applied. The H–index, which incorporates frequency and intensity of staining of the cells, and can range from 0 to 300, was deemed positive when it exceeded 9. Among premenopausal women, there was no evidence for an association with breast cancer risk for expression of either type of receptors. Among postmenopausal women, breast cancer risk was inversely associated with expression of both estrogen alpha (odds ratio (OR) = 0.39;p= 0.015) and progesterone (OR = 0.40;p= 0.008) receptors. The hypothesis that overexpression of estrogen receptors alpha or progesterone receptors in normal breast epithelium may increase the risk of breast cancer was not supported by our data. Instead, we found evidence that overexpression of these receptors may be associated with reduced risk for breast cancer in line with the well‐known association of expression of these receptors in the malignant tissue and better breast cancer prognosis. © 2008 Wiley‐Liss, Inc.