Chloroquine use improves dengue-related symptoms
Chloroquine use improves dengue-related symptoms
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DOI：
10.1590/s0074-02762013000500010
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发表时间：
2013-08-01
期刊：
影响因子：
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通讯作者：
Fonseca, Benedito Antonio Lopes da
中科院分区：
文献类型：
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作者：
Borges, Marcos Carvalho;Castro, Luiza Antunes;Fonseca, Benedito Antonio Lopes da
登革热是世界上最重要的虫媒病毒性疾病。由于氯喹是一种抗疟药，已显示出一定的抗病毒作用，本研究评估了其在登革热患者中的作用。一项随机、双盲研究对129名有登革热相关症状的患者进行了为期三天的氯喹或安慰剂治疗。在这些患者中，37名被确认患有登革热并完成了研究;总共有19名登革热患者接受了氯喹，18名接受了安慰剂。病程长短、发热程度、发热天数无明显差异。然而，12名确诊登革热的患者（63%）报告说，在服药期间，疼痛强度大幅下降，日常活动能力大幅改善（p = 0.0004），这些患者停止服药后症状立即恢复。在登革热以外的疾病患者中没有观察到同样的效果。因此，这项研究表明，接受氯喹治疗的登革热患者的生活质量有所改善，并且能够恢复日常活动。然而，由于氯喹不会改变疾病的持续时间或发烧的强度和天数，因此需要进一步研究以确认氯喹对登革热患者的临床效果并评估其副作用。
Dengue is the most important arboviral disease in the world. As chloroquine, an antimalarial agent, has shown some antiviral effects, this study evaluated its effect in patients with dengue. A randomised, double-blind study was performed by administering chloroquine or placebo for three days to 129 patients with dengue-related symptoms. Of these patients, 37 were confirmed as having dengue and completed the study; in total, 19 dengue patients received chloroquine and 18 received placebo. There was no significant difference in the duration of the disease or the degree and days of fever. However, 12 patients (63%) with confirmed dengue reported a substantial decrease in pain intensity and a great improvement in their ability to perform daily activities (p = 0.0004) while on the medication and the symptoms returned immediately after these patients stopped taking the medication. The same effect was not observed in patients with diseases other than dengue. Therefore, this study shows that patients with dengue treated with chloroquine had an improvement in their quality of life and were able to resume their daily activities. However, as chloroquine did not alter the duration of the disease or the intensity and days of fever, further studies are necessary to confirm the clinical effects and to assess the side effects of chloroquine in dengue patients.