RELATIONSHIP BETWEEN TOCOPHEROL AND SERUM-LIPID LEVELS FOR DETERMINATION OF NUTRITIONAL ADEQUACY
RELATIONSHIP BETWEEN TOCOPHEROL AND SERUM-LIPID LEVELS FOR DETERMINATION OF NUTRITIONAL ADEQUACY
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DOI：
10.1111/j.1749-6632.1972.tb27878.x
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发表时间：
1972-01-01
影响因子：
5.2
通讯作者：
SEARCY, MT
中科院分区：
文献类型：
--
作者：
HORWITT, MK;HARVEY, CC;SEARCY, MT
这篇文章的目的是证明目前从血液水平数据对维生素E营养状况的解释是不充分的，并提出一种纠正这种情况的方法。一段时间以来，人们已经知道血清胆固醇水平与硒中总生育酚的水平有关。最近，几个实验室报道了血清生育酚与血清脂蛋白和其他脂质组分的关系。由于当其他因素，如年龄、怀孕、蛋白质缺乏和各种疾病状态引起血脂变化时，与维生素E摄入量无关的血液生育酚水平会发生变化，因此人们面临这样一个事实，即对血清生育酚的测定可能会给出关于组织中生育酚水平的错误信息。此外，由于血液中可能只有大约1%的全身生育酚，而过氧化氢溶血试验在很大程度上取决于血液中生育酚的水平，因此，除非知道血脂水平，否则即使是这种红细胞对氧化的相对敏感性的测试也可能失去作用。这份报告将确认和检查血清脂质-生育酚关系的那些方面，这些方面提供的信息可以从相对生育酚营养的数字陈述中得出。提供的数据分为五个部分。首先，来自先前另一项研究的数据将显示，当患者服用控制生育酚摄入量的饮食时，患者服用三碘甲状腺原氨酸(T3)时发生的变化。第二部分描述了通过药物和饮食相结合的方式提高血脂的大鼠的实验，以确定通过提高血脂水平可以提高血清生育酚水平的程度。第三部分说明了在婴儿从蛋白质-卡路里营养不良中恢复的研究中观察到的变化，同时给他们喂食含有相对较低水平的生育酚的受控饮食。第四部分包括从出生到成熟的不同年龄的各种患者的血浆分析数据，以说明可以获得的数据范围。第五部分比较了出生时从母亲和孩子那里获得的数据。
The purpose of this paper is to show that current interpretations of the status of vitamin E nutrition from blood level data are inadequate, and to suggest a means of remedying the situation.It has been known for some time that the serum level of cholesterol can be related to the level of the total tocopherol in the se~ um.~-~ More recently, the relationship of serum tocopherol to serum lipoproteins and other lipid fractions has been reported by several laboratories." Since changes not related to the amounts of vitamin E ingested can occur in the blood levels of the tocopherols when other factors such as age, pregnancy, protein deficiency, and a variety of disease states cause changes in the blood lipids, one is faced with the fact that a determination of the serum tocopherol may give erroneous information about the level of tocopherol in the tissues. Furthermore, since only about 1% of the total body tocopherol may be in the blood, and the peroxide hemolysis test is largely dependent on the level of tocopherols in the blood, even this test of the relative susceptibility of the erythrocyte to oxidation may lose its usefulness unless the blood lipid levels are known. This report will confirm and examine those aspects of the serum lipid-tocopherol relationships that provide information from which a numerical statement of relative tocopherol nutrition may be derived. The data presented are divided into five sections. First, data from a previous study, designed for a different purpose, will show the changes that occurred when patients who were fed diets in which their tocopherol intake were controlled were given triiodothyronine (T3). The second section describes experiments with rats whose lipids were increased by a combination of drugs and dietary means, in order to determine how much one can elevate the serum levels of tocopherol by increasing the blood lipid levels. A third section illustrates the changes observed during studies of infants recovering from protein-calorie malnutrition while they were fed controlled diets that contained relatively low levels of tocopherol. The fourth section includes data on the analysis of plasma from a variety of patients, at various ages from birth to maturity, to illustrate the range of data that can be obtained. The fifth section compares the data obtained from mother and child at the time of birth.