Effect of amphetamine on response inhibition in rats showing high or low response to novelty
Effect of amphetamine on response inhibition in rats showing high or low response to novelty
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DOI：
10.1016/j.pbb.2006.07.015
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发表时间：
2006-09-01
影响因子：
3.6
通讯作者：
Bylica, K. E.
中科院分区：
文献类型：
--
作者：
Bardo, M. T.;Cain, M. E.;Bylica, K. E.
先前的研究表明，根据在新环境中评估的活动量，将大鼠分为高反应者（HR）或低反应者（LR），对刺激性奖励表现出不同的反应，HR大鼠自我给予的安非他明和可卡因比LR大鼠多。本研究使用固定连续数（FCN）或低反应率（DRL）任务的差异强化来评估HR和LR大鼠的行为抑制过程。个体差异的自由选择偏好的一个新的环境或新的对象进行了评估，以确定这些措施是预测这些抑制任务的性能。结果表明，无论用于表征个体差异的测试，以新奇性，组显示出类似的学习能力的FCN和DRL任务。当随后预处理安非他明，有没有显着差异组之间的表现效率（准确性）上的FCN或DRL任务，但是，基于活动在不可避免的新奇，HR大鼠不太敏感比LR大鼠安非他明中断响应上的FCN任务的强化杠杆。虽然抑制缺陷通常被认为在药物滥用行为中发挥作用，但先前描述的HR和LR大鼠之间的兴奋剂自我给药的差异率更可能反映了独立于反应抑制的激励激励效应。(c)2006年爱思唯尔公司All rights reserved.
Previous work has shown that rats categorized as either high responder (HR) or low responder (LR) based on the amount of activity assessed in a novel environment show a differential response to stimulant reward, with HR rats self-administering more amphetamine and cocaine than LR rats. The current study assessed behavioral inhibitory processes in HR and LR rats using either fixed consecutive number (FCN) or differential reinforcement of low rate of responding (DRL) tasks. Individual differences in free-choice preference for a novel environment or novel object were also assessed to determine if these measures were predictive of performance on these inhibitory tasks. Results showed that, regardless of the test used to characterize individual differences in response to novelty, groups showed a similar ability to learn the FCN and DRL tasks. When subsequently pretreated with amphetamine, there was no significant difference between groups in performance efficiency (accuracy) on either the FCN or DRL task; however, based on activity in inescapable novelty, HR rats were less sensitive than LR rats to amphetamine-disrupted responding on the reinforcement lever in the FCN task. Although a deficit in inhibition is generally thought to play a role in drug abuse behavior, the differential rate of stimulant self-administration described previously between HR and LR rats more likely reflects an incentive motivational effect that is independent of response inhibition. (c) 2006 Elsevier Inc. All rights reserved.